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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2006-4-27
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pubmed:abstractText |
Lissoclimides are cytotoxic compounds produced by shell-less molluscs through chemical secretions to deter predators. Chlorinated lissoclimides were identified as the active component of a marine extract from Pleurobranchus forskalii found during a high-throughput screening campaign to characterize new protein synthesis inhibitors. It was demonstrated that these compounds inhibit protein synthesis in vitro, in extracts prepared from mammalian and plant cells, as well as in vivo against mammalian cells. Our results suggest that they block translation elongation by inhibiting translocation, leading to an accumulation of ribosomes on mRNA. These data provide a rationale for the cytotoxic nature of this class of small molecule natural products.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-10581244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-11063617,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-11333019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-11575950,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-12533507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-1337432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-14769948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-14770004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-14970397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-15029198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-15081300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-15094766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-15332867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-15568798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-15577254,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-16030146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-16193158,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-1647921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-1703007,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-221915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-2754719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-3365303,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-5541758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-6027796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-7619818,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16540697-7909440
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Elongation Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides, Cyclic,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Synthesis Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Puromycin,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Transfer, Phe,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/methionylpuromycin
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1355-8382
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
717-25
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16540697-Animals,
pubmed-meshheading:16540697-Dose-Response Relationship, Drug,
pubmed-meshheading:16540697-Eukaryotic Cells,
pubmed-meshheading:16540697-HeLa Cells,
pubmed-meshheading:16540697-Humans,
pubmed-meshheading:16540697-Inhibitory Concentration 50,
pubmed-meshheading:16540697-Molecular Structure,
pubmed-meshheading:16540697-Mollusca,
pubmed-meshheading:16540697-Nuclear Proteins,
pubmed-meshheading:16540697-Peptide Chain Elongation, Translational,
pubmed-meshheading:16540697-Peptide Elongation Factor 2,
pubmed-meshheading:16540697-Peptides, Cyclic,
pubmed-meshheading:16540697-Protein Biosynthesis,
pubmed-meshheading:16540697-Protein Synthesis Inhibitors,
pubmed-meshheading:16540697-Puromycin,
pubmed-meshheading:16540697-RNA, Messenger,
pubmed-meshheading:16540697-RNA, Transfer, Phe,
pubmed-meshheading:16540697-Ribosomes,
pubmed-meshheading:16540697-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Chlorolissoclimides: new inhibitors of eukaryotic protein synthesis.
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pubmed:affiliation |
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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