Source:http://linkedlifedata.com/resource/pubmed/id/16539539
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-3-16
|
| pubmed:abstractText |
The accurate computational prediction of T-cell epitopes can greatly reduce the experimental overhead implicit in candidate epitope identification within genomic sequences. In this article we present MHCPred 2.0, an enhanced version of our online, quantitative T-cell epitope prediction server. The previous version of MHCPred included mostly alleles from the human leukocyte antigen A (HLA-A) locus. In MHCPred 2.0, mouse models are added and computational constraints removed. Currently the server includes 11 human HLA class I, three human HLA class II, and three mouse class I models. Additionally, a binding model for the human transporter associated with antigen processing (TAP) is incorporated into the new MHCPred. A tool for the design of heteroclitic peptides is also included within the server. To refine the veracity of binding affinities prediction, a confidence percentage is also now calculated for each peptide predicted. AVAILABILITY: As previously, MHCPred 2.0 is freely available at the URL http://www.jenner.ac.uk/MHCPred/ CONTACT: Darren R. Flower (darren.flower@jenner.ac.uk).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
1175-5636
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
5
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
55-61
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| pubmed:dateRevised |
2010-4-12
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| pubmed:meshHeading |
pubmed-meshheading:16539539-Algorithms,
pubmed-meshheading:16539539-Animals,
pubmed-meshheading:16539539-Antigen Presentation,
pubmed-meshheading:16539539-Binding Sites,
pubmed-meshheading:16539539-Computer Simulation,
pubmed-meshheading:16539539-Epitopes, T-Lymphocyte,
pubmed-meshheading:16539539-Histocompatibility Antigens,
pubmed-meshheading:16539539-Humans,
pubmed-meshheading:16539539-Internet,
pubmed-meshheading:16539539-Major Histocompatibility Complex,
pubmed-meshheading:16539539-Mice,
pubmed-meshheading:16539539-Models, Chemical,
pubmed-meshheading:16539539-Models, Molecular,
pubmed-meshheading:16539539-Online Systems,
pubmed-meshheading:16539539-Peptides,
pubmed-meshheading:16539539-Protein Binding,
pubmed-meshheading:16539539-Sequence Analysis, Protein,
pubmed-meshheading:16539539-Software,
pubmed-meshheading:16539539-User-Computer Interface
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
MHCPred 2.0: an updated quantitative T-cell epitope prediction server.
|
| pubmed:affiliation |
Edward Jenner Institute for Vaccine Research, Compton, Berkshire, UK.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|