|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0013058,
umls-concept:C0031336,
umls-concept:C0086982,
umls-concept:C0205177,
umls-concept:C0205314,
umls-concept:C0332206,
umls-concept:C0422392,
umls-concept:C0449432,
umls-concept:C0679622,
umls-concept:C0752270,
umls-concept:C1179435,
umls-concept:C1280500,
umls-concept:C1332709,
umls-concept:C1524073,
umls-concept:C1548799,
umls-concept:C1553890,
umls-concept:C1705248
|
|
pubmed:issue |
6
|
|
pubmed:dateCreated |
2006-3-16
|
|
pubmed:abstractText |
AFTIR (after flowing through immobilized receptor) is a novel method for screening herbal extracts for pharmaceutical properties. Using AFTIR, we identified Cynarin in Echinacea purpurea by its selective binding to chip immobilized CD28, a receptor of T-cells, which is instrumental to immune functioning. The results of surface plasma resonance show that binding between immobilized CD28 and Cynarin is stronger than the binding between CD28 and CD80, a co-stimulated receptor of antigen presenting cells. Cynarin's function was verified by its ability to downregulate CD28-dependent interleukin-2 (IL-2) expression in a T-cell culture line. AFTIR offers promise as an efficient screening method for herbal medicines.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD28,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Cinnamates,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin Fc Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunosuppressive Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/cynarine
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0022-2623
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
23
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
1845-54
|
|
pubmed:dateRevised |
2009-10-8
|
|
pubmed:meshHeading |
pubmed-meshheading:16539370-Animals,
pubmed-meshheading:16539370-Antigens, CD28,
pubmed-meshheading:16539370-Antigens, CD80,
pubmed-meshheading:16539370-Chromatography, High Pressure Liquid,
pubmed-meshheading:16539370-Cinnamates,
pubmed-meshheading:16539370-Echinacea,
pubmed-meshheading:16539370-Humans,
pubmed-meshheading:16539370-Immunoglobulin Fc Fragments,
pubmed-meshheading:16539370-Immunoglobulin G,
pubmed-meshheading:16539370-Immunosuppressive Agents,
pubmed-meshheading:16539370-Interleukin-2,
pubmed-meshheading:16539370-Jurkat Cells,
pubmed-meshheading:16539370-Mice,
pubmed-meshheading:16539370-Plant Extracts,
pubmed-meshheading:16539370-Recombinant Fusion Proteins,
pubmed-meshheading:16539370-Signal Transduction,
pubmed-meshheading:16539370-Surface Plasmon Resonance,
pubmed-meshheading:16539370-T-Lymphocytes
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Immuno-suppressive effect of blocking the CD28 signaling pathway in T-cells by an active component of Echinacea found by a novel pharmaceutical screening method.
|
|
pubmed:affiliation |
Institute of BioAgricultural Sciences, Academia Sinica, Taipei, Taiwan 115, Republic of China.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
