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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-22
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pubmed:abstractText |
Bone marrow normal lymphoid progenitors (CD19+, CD10+, and/or CD34+) are exquisitely sensitive to corticosteroids and other antileukemic drugs. We hypothesized that, in patients with B-lineage acute lymphoblastic leukemia (ALL), cells with this phenotype detected early in treatment should be leukemic rather than normal. We therefore developed a simple and inexpensive flow cytometric assay for such cells and prospectively applied it to bone marrow samples collected on day 19 from 380 children with B-lineage ALL. In 211 patients (55.5%), these cells represented 0.01% or more of the mononuclear cells; results correlated remarkably well with those of more complex flow cytometric and molecular minimal residual disease (MRD) evaluations. Among 84 uniformly treated children, the 10-year incidence of relapse or remission failure was 28.8% +/- 7.1% (SE) for the 42 patients with 0.01% or more leukemic cells on day 19 detected by the simplified assay versus 4.8% +/- 3.3% for the 42 patients with lower levels (P = .003). These assay results were the strongest predictor of outcome, even after adjustment for competing clinicobiologic variables. Thus, this new assay would enable most treatment centers to identify a high proportion of children with ALL who have an excellent early treatment response and a high likelihood of cure.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-10438708,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-10450750,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-10648387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-10735899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-10749961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-10986407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-11023499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-11902549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-11905735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-12070006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-12070008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-12199771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-12704389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-12786792,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-12799535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-1389177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-15029212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-15071128,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-15161898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-15251979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-15917380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-2685179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-6589042,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-7632935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-7869771,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-8636748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-9060558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-9207407,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-9492773,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-9657739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-9763557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-9844930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16537802-9848348
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0006-4971
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
108
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
97-102
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16537802-Antigens, CD19,
pubmed-meshheading:16537802-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16537802-Burkitt Lymphoma,
pubmed-meshheading:16537802-Child,
pubmed-meshheading:16537802-Child, Preschool,
pubmed-meshheading:16537802-Female,
pubmed-meshheading:16537802-Flow Cytometry,
pubmed-meshheading:16537802-Humans,
pubmed-meshheading:16537802-Infant,
pubmed-meshheading:16537802-Infant, Newborn,
pubmed-meshheading:16537802-Lymphocytes,
pubmed-meshheading:16537802-Male,
pubmed-meshheading:16537802-Neoplasm, Residual,
pubmed-meshheading:16537802-Phenotype,
pubmed-meshheading:16537802-Precursor Cell Lymphoblastic Leukemia-Lymphoma,
pubmed-meshheading:16537802-Prognosis,
pubmed-meshheading:16537802-Recurrence,
pubmed-meshheading:16537802-Remission Induction,
pubmed-meshheading:16537802-Sensitivity and Specificity,
pubmed-meshheading:16537802-Treatment Outcome
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pubmed:year |
2006
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pubmed:articleTitle |
A simplified flow cytometric assay identifies children with acute lymphoblastic leukemia who have a superior clinical outcome.
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pubmed:affiliation |
Department of Hematology-Oncology, and International Outreach Progrm, St Jude Children's Research Hospital, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Evaluation Studies,
Research Support, N.I.H., Extramural
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