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rdf:type |
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lifeskim:mentions |
umls-concept:C0019425,
umls-concept:C0026809,
umls-concept:C0031740,
umls-concept:C0205148,
umls-concept:C0332237,
umls-concept:C0439064,
umls-concept:C0694887,
umls-concept:C1367881,
umls-concept:C1522168,
umls-concept:C1705339,
umls-concept:C1826732,
umls-concept:C1883017
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pubmed:issue |
4
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pubmed:dateCreated |
2006-3-15
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pubmed:abstractText |
Photodynamic therapy (PDT) combines the administration of a photosensitizer with its subsequent activation by light of the appropriate wavelength. Methylaminolaevulinate (MAL) is a photosensitizer precursor, transformed by cells into protoporphyrin IX. The PTCH gene plays a central role in the genesis of basal cell carcinoma (BCC). The PTCH transgenic mouse develops microscopic BCCs when chronically exposed to ultraviolet (UV) or ionizing radiation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0007-0963
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
154
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
740-2
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16536820-Aminolevulinic Acid,
pubmed-meshheading:16536820-Animals,
pubmed-meshheading:16536820-Carcinoma, Basal Cell,
pubmed-meshheading:16536820-Female,
pubmed-meshheading:16536820-Genetic Predisposition to Disease,
pubmed-meshheading:16536820-Heterozygote,
pubmed-meshheading:16536820-Mice,
pubmed-meshheading:16536820-Mice, Transgenic,
pubmed-meshheading:16536820-Neoplasms, Radiation-Induced,
pubmed-meshheading:16536820-Photochemotherapy,
pubmed-meshheading:16536820-Photosensitizing Agents,
pubmed-meshheading:16536820-Receptors, Cell Surface,
pubmed-meshheading:16536820-Skin Neoplasms,
pubmed-meshheading:16536820-Ultraviolet Rays
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pubmed:year |
2006
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pubmed:articleTitle |
Multiple large surface photodynamic therapy sessions with topical methylaminolaevulinate in PTCH heterozygous mice.
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pubmed:affiliation |
University of Montreal Hospital Center, Dermatology, Montreal, Quebec, Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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