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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-3-15
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pubmed:abstractText |
The interaction between the HIV-1 Rev protein and the Rev-Responsive Element (RRE) RNA is an attractive target for anti-viral therapy. We have designed alpha-helical peptidomimetics of Rev-like peptides using side chain-side chain macrolactam formation between positions i and i+4. One peptidomimetic having an appropriate location, orientation, and length of the macrolactam exhibited both significant helical character and specific RRE binding. This molecule displays 2-fold greater RNA specificity than the wild-type Rev peptide and more than 20-fold greater specificity than an uncyclized control peptide. Thus, specific, high affinity recognition of the RRE is feasible utilizing a small, relatively rigid peptidomimetic scaffold.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-10449725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-10764789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-10853671,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-11456738,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-12925996,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-14631848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-14677935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-2481237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-2556643,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-2784194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-7684657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-7830591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-8703216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-8850540,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16536504-9539722
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-7863
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
22
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pubmed:volume |
128
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3496-7
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pubmed:dateRevised |
2011-4-14
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pubmed:meshHeading |
pubmed-meshheading:16536504-Amino Acid Sequence,
pubmed-meshheading:16536504-Anti-HIV Agents,
pubmed-meshheading:16536504-Biomimetic Materials,
pubmed-meshheading:16536504-Circular Dichroism,
pubmed-meshheading:16536504-Gene Products, rev,
pubmed-meshheading:16536504-Genes, env,
pubmed-meshheading:16536504-HIV-1,
pubmed-meshheading:16536504-Molecular Sequence Data,
pubmed-meshheading:16536504-Oligopeptides,
pubmed-meshheading:16536504-Protein Structure, Secondary,
pubmed-meshheading:16536504-RNA, Viral,
pubmed-meshheading:16536504-rev Gene Products, Human Immunodeficiency Virus
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pubmed:year |
2006
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pubmed:articleTitle |
An alpha-helical peptidomimetic inhibitor of the HIV-1 Rev-RRE interaction.
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pubmed:affiliation |
Department of Biochemistry and Biophysics, University of California, San Francisco, California 94143-2280, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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