| pubmed-article:16533885 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16533885 | lifeskim:mentions | umls-concept:C0039198 | lld:lifeskim |
| pubmed-article:16533885 | lifeskim:mentions | umls-concept:C1416467 | lld:lifeskim |
| pubmed-article:16533885 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:16533885 | lifeskim:mentions | umls-concept:C0205296 | lld:lifeskim |
| pubmed-article:16533885 | lifeskim:mentions | umls-concept:C1291775 | lld:lifeskim |
| pubmed-article:16533885 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16533885 | pubmed:dateCreated | 2006-3-21 | lld:pubmed |
| pubmed-article:16533885 | pubmed:abstractText | Natural regulatory T (T reg) cells are involved in control of the immune response, including response to pathogens. Previous work has demonstrated that the repertoire of natural T reg cells may be biased toward self-antigen recognition. Whether they also recognize foreign antigens and how this recognition contributes to their function remain unknown. Our studies addressed the antigenic specificity of natural T reg cells that accumulate at sites of chronic infection with Leishmania major in mice. Our results support the idea that natural T reg cells are able to respond specifically to foreign antigens in that they strongly proliferate in response to Leishmania-infected dendritic cells, they maintain Foxp3 expression, and Leishmania-specific T reg cell lines can be generated from infected mice. Surprisingly, the majority of natural T reg cells at the infected site are Leishmania specific. Further, we showed that parasite-specific natural T reg cells are restricted to sites of infection and that their survival is strictly dependent on parasite persistence. | lld:pubmed |
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| pubmed-article:16533885 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16533885 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16533885 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16533885 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16533885 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16533885 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:16533885 | pubmed:author | pubmed-author:PiccirilloCir... | lld:pubmed |
| pubmed-article:16533885 | pubmed:author | pubmed-author:BelkaidYasmin... | lld:pubmed |
| pubmed-article:16533885 | pubmed:author | pubmed-author:GoldszmidRomi... | lld:pubmed |
| pubmed-article:16533885 | pubmed:author | pubmed-author:RecklingStaci... | lld:pubmed |
| pubmed-article:16533885 | pubmed:author | pubmed-author:SuffiaIsabell... | lld:pubmed |
| pubmed-article:16533885 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16533885 | pubmed:day | 20 | lld:pubmed |
| pubmed-article:16533885 | pubmed:volume | 203 | lld:pubmed |
| pubmed-article:16533885 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16533885 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16533885 | pubmed:pagination | 777-88 | lld:pubmed |
| pubmed-article:16533885 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:16533885 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16533885 | pubmed:articleTitle | Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens. | lld:pubmed |
| pubmed-article:16533885 | pubmed:affiliation | Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA. | lld:pubmed |
| pubmed-article:16533885 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16533885 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| pubmed-article:16533885 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| pubmed-article:16533885 | pubmed:publicationType | Research Support, N.I.H., Intramural | lld:pubmed |
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