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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-3-21
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pubmed:abstractText |
Natural regulatory T (T reg) cells are involved in control of the immune response, including response to pathogens. Previous work has demonstrated that the repertoire of natural T reg cells may be biased toward self-antigen recognition. Whether they also recognize foreign antigens and how this recognition contributes to their function remain unknown. Our studies addressed the antigenic specificity of natural T reg cells that accumulate at sites of chronic infection with Leishmania major in mice. Our results support the idea that natural T reg cells are able to respond specifically to foreign antigens in that they strongly proliferate in response to Leishmania-infected dendritic cells, they maintain Foxp3 expression, and Leishmania-specific T reg cell lines can be generated from infected mice. Surprisingly, the majority of natural T reg cells at the infected site are Leishmania specific. Further, we showed that parasite-specific natural T reg cells are restricted to sites of infection and that their survival is strictly dependent on parasite persistence.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-10037236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-11714756,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-11748963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-11920289,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12103341,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12466842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12591899,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12633655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12658273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12682220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12857946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12874257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12874258,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-12975455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-1351500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-14647055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-14684420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-14702631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-14963140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-14978122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15032588,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15036231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15036234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15184499,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15240714,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15252446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15263027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15271794,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15280419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15308106,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15486925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15545984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15720442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15749840,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15780990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15785758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15785761,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-15795373,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-9463379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-9565379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16533885-9782133
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
203
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
777-88
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16533885-Animals,
pubmed-meshheading:16533885-Antigens, Protozoan,
pubmed-meshheading:16533885-Cell Line,
pubmed-meshheading:16533885-Cell Proliferation,
pubmed-meshheading:16533885-Chronic Disease,
pubmed-meshheading:16533885-Dendritic Cells,
pubmed-meshheading:16533885-Forkhead Transcription Factors,
pubmed-meshheading:16533885-Gene Expression Regulation,
pubmed-meshheading:16533885-Leishmania major,
pubmed-meshheading:16533885-Leishmaniasis, Cutaneous,
pubmed-meshheading:16533885-Mice,
pubmed-meshheading:16533885-Mice, Knockout,
pubmed-meshheading:16533885-Species Specificity,
pubmed-meshheading:16533885-T-Lymphocytes, Regulatory
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pubmed:year |
2006
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pubmed:articleTitle |
Infected site-restricted Foxp3+ natural regulatory T cells are specific for microbial antigens.
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pubmed:affiliation |
Mucosal Immunology Unit, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, MD 20892, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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