Linked Life Data

16532006

Source:http://linkedlifedata.com/resource/pubmed/id/16532006

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-5-22
pubmed:databankReference
pubmed:abstractText
The replication of flaviviruses requires the correct processing of their polyprotein by the viral NS3 protease (NS3pro). Essential for the activation of NS3pro is a 47-residue region of NS2B. Here we report the crystal structures of a dengue NS2B-NS3pro complex and a West Nile virus NS2B-NS3pro complex with a substrate-based inhibitor. These structures identify key residues for NS3pro substrate recognition and clarify the mechanism of NS3pro activation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1545-9993
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
372-3
pubmed:dateRevised
2006-12-8
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Structural basis for the activation of flaviviral NS3 proteases from dengue and West Nile virus.
pubmed:affiliation
Novartis Institutes for Biomedical Research, Protease Platform, 4002 Basel, Switzerland.
pubmed:publicationType
Journal Article