Linked Life Data

16531632

Source:http://linkedlifedata.com/resource/pubmed/id/16531632

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-3-13
pubmed:abstractText
Ulmus davidiana Nakai (UDN) has been used for a long time to cure inflammation in oriental medicine. To evaluate the cytoprotective effects of the UDN glycoprotein, we measured cytotoxicity, the level of intracellular reactive oxygen species (ROS), activity of nuclear factor-kappaB (NF-kappaB), nitric oxide (NO) production, and thiobarbituric acid-reactive substances (TBARS) formation in 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated BNL CL.2 cells. In TPA-treated BNL CL.2 cells, the results showed that UDN glycoprotein has dose-dependent blocking activities against TPA-induced cytotoxicity and NF-kappaB activation. In cytotoxic-related events, UDN glycoprotein (200 microg/ml) has an inhibitory effect on intracellular ROS production, NO production, and TBARS formation, without any toxic effects in the BNL CL.2 cells. These results suggest that UDN glycoprotein has cytoprotective abilities against TPA-induced oxidative cell injury.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1734-1140
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
67-74
pubmed:dateRevised
2008-5-28
pubmed:meshHeading
pubmed:articleTitle
Glycoprotein (116 kD) isolated from Ulmus davidiana Nakai protects from injury of 12-O-tetradecanoylphorbol 13-acetate (TPA)-treated BNL CL.2 cells.
pubmed:affiliation
Molecular Biochemistry Laboratory, Institute of Biotechnology, Chonnam National University, 300 Yongbong-Dong, Kwangju City, 500-757, South Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't