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pubmed-article:16528530pubmed:abstractTextThe purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in reducing 5-fluorouracil (FUra) host-toxicity and enhancing its chemotherapeutic efficacy against human colon tumors. PTAU is a potent and specific inhibitor of uridine phosphorylase (UrdPase, EC 2.4.2.3), the enzyme responsible for uridine catabolism.lld:pubmed
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pubmed-article:16528530pubmed:articleTitleModulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.lld:pubmed
pubmed-article:16528530pubmed:affiliationDepartment of Pharmacology and Toxicology, Comprehensive Cancer Center, Center for Aids Research, University of Alabama at Birmingham, Birmingham, AL 35294, USA.lld:pubmed
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