|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2006-8-9
|
|
pubmed:abstractText |
The purpose of this investigation was to evaluate the effectiveness of oral 5-(phenylthio)acyclouridine (PTAU) in reducing 5-fluorouracil (FUra) host-toxicity and enhancing its chemotherapeutic efficacy against human colon tumors. PTAU is a potent and specific inhibitor of uridine phosphorylase (UrdPase, EC 2.4.2.3), the enzyme responsible for uridine catabolism.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Nov
|
|
pubmed:issn |
0344-5704
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
58
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
692-8
|
|
pubmed:dateRevised |
2007-11-14
|
|
pubmed:meshHeading |
pubmed-meshheading:16528530-Administration, Oral,
pubmed-meshheading:16528530-Animals,
pubmed-meshheading:16528530-Antimetabolites, Antineoplastic,
pubmed-meshheading:16528530-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16528530-Body Weight,
pubmed-meshheading:16528530-Cell Line, Tumor,
pubmed-meshheading:16528530-Colonic Neoplasms,
pubmed-meshheading:16528530-Dose-Response Relationship, Drug,
pubmed-meshheading:16528530-Enzyme Inhibitors,
pubmed-meshheading:16528530-Fluorouracil,
pubmed-meshheading:16528530-Humans,
pubmed-meshheading:16528530-Male,
pubmed-meshheading:16528530-Mice,
pubmed-meshheading:16528530-Mice, SCID,
pubmed-meshheading:16528530-Survival Analysis,
pubmed-meshheading:16528530-Thiouracil,
pubmed-meshheading:16528530-Uridine,
pubmed-meshheading:16528530-Uridine Phosphorylase,
pubmed-meshheading:16528530-Xenograft Model Antitumor Assays
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor.
|
|
pubmed:affiliation |
Department of Pharmacology and Toxicology, Comprehensive Cancer Center, Center for Aids Research, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
