Linked Life Data

16528528

Source:http://linkedlifedata.com/resource/pubmed/id/16528528

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-9-5
pubmed:abstractText
Ferredoxin reductase (FDXR) is a putative contributor to p53-mediated apoptosis from 5-fluorouracil (5-FU) through the generation of oxidative stress in the mitochondria. However, the influence of FDXR gene expression levels on the outcome of 5-FU chemotherapy has been relatively little studied. The aim of this study is to investigate the association between FDXR gene expressions and the clinical outcome when treated by 5-FU chemotherapy, as well as the correlation of FDXR gene expressions and p53 mutation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0344-5704
pubmed:author
pubmed:issnType
Print
pubmed:volume
58
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
794-801
pubmed:meshHeading
pubmed-meshheading:16528528-Adult, pubmed-meshheading:16528528-Aged, pubmed-meshheading:16528528-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:16528528-Colorectal Neoplasms, pubmed-meshheading:16528528-DNA Mutational Analysis, pubmed-meshheading:16528528-Ferredoxin-NADP Reductase, pubmed-meshheading:16528528-Fluorouracil, pubmed-meshheading:16528528-Frameshift Mutation, pubmed-meshheading:16528528-Gene Expression, pubmed-meshheading:16528528-Gene Expression Regulation, Enzymologic, pubmed-meshheading:16528528-Gene Expression Regulation, Neoplastic, pubmed-meshheading:16528528-Humans, pubmed-meshheading:16528528-Leucovorin, pubmed-meshheading:16528528-Middle Aged, pubmed-meshheading:16528528-Mutation, Missense, pubmed-meshheading:16528528-Neoplasm Metastasis, pubmed-meshheading:16528528-Prognosis, pubmed-meshheading:16528528-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:16528528-Survival Analysis, pubmed-meshheading:16528528-Treatment Outcome, pubmed-meshheading:16528528-Tumor Suppressor Protein p53
pubmed:year
2006
pubmed:articleTitle
Gene expression of ferredoxin reductase predicts outcome in patients with metastatic colorectal cancer treated by 5-fluorouracil plus leucovorin.
pubmed:affiliation
Department of General and Digestive Surgery, Saitama Medical School, 38, Moro-Hongo, Moroyama, Iruma, 350-049, Saitama, Japan. wataru@saitama-med.ac.jp
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't