Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-4-14
pubmed:abstractText
Understanding protein function from its structure is a challenging problem. Sequence based approaches for finding homology have broad use for annotation of both structure and function. 3D structural information of protein domains and their interactions provide a complementary view to structure function relationships to sequence information. We have developed a web site http://www.sblest.org/ and an API of web services that enables users to submit protein structures and identify statistically significant neighbors and the underlying structural environments that make that match using a suite of sequence and structure analysis tools. To do this, we have integrated S-BLEST, PSI-BLAST and HMMer based superfamily predictions to give a unique integrated view to prediction of SCOP superfamilies, EC number, and GO term, as well as identification of the protein structural environments that are associated with that prediction. Additionally, we have extended UCSF Chimera and PyMOL to support our web services, so that users can characterize their own proteins of interest.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-10498773, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-10592235, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-10812475, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-11524379, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-11697912, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-11790846, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-12603031, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-12651721, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-12824318, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-12824322, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-14681391, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-14681407, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-14985506, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-15215342, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-15264254, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-15608188, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-15759639, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-15937274, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-15963890, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-15980588, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-16245324, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-7613462, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-7723011, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-9016542, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-9254694, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-9405143, http://linkedlifedata.com/resource/pubmed/commentcorrection/16526955-9796821
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1472-6807
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Identification of similar regions of protein structures using integrated sequence and structure analysis tools.
pubmed:affiliation
Center for Computational Biology and Bioinformatics, Indiana University School of Medicine, Indianapolis, IN 46202, USA. brandon@compbio.iupui.edu
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't