Linked Life Data

16526782

Source:http://linkedlifedata.com/resource/pubmed/id/16526782

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-3-10
pubmed:abstractText
The concept of molecular simplification as a drug design strategy to shorten synthetic routes, while keeping or enhancing the biological activity of the lead drug, has been applied to (+)-muconin, an acetogenin with remarkable cytotoxicity. A novel approach that enables the stereoselective synthesis of such a natural compound or its enantiomer from a common precursor is described. An additional advantage of the method is complete stereochemical control and the decrease in the number of chemical steps required, thus providing an enhancement of the overall yield. Antiproliferative studies against the human solid tumor cell lines showed that the aliphatic chain-THF/THP fragment of (+)-muconin has modest cytotoxic activity. The strategy opens the way to preparing novel bioactive acetogenin analogues by shorter synthetic routes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0022-3263
pubmed:author
pubmed:issnType
Print
pubmed:day
17
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2339-45
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Molecular simplification in bioactive molecules: formal synthesis of (+)-muconin.
pubmed:affiliation
Instituto Universitario de Bio-Organica Antonio Gonzalez, Universidad de La Laguna, Astrofísico Astrofísico Francisco Sanchez 2, 38206 La Laguna, Tenerife, Islas Canarias, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't