|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0015684,
umls-concept:C0017262,
umls-concept:C0017337,
umls-concept:C0030274,
umls-concept:C0030281,
umls-concept:C0086418,
umls-concept:C0185117,
umls-concept:C0242363,
umls-concept:C0332120,
umls-concept:C0597357,
umls-concept:C1256369,
umls-concept:C1825292,
umls-concept:C2911684
|
|
pubmed:issue |
5
|
|
pubmed:dateCreated |
2006-4-27
|
|
pubmed:abstractText |
G protein-coupled receptor 40 (GPR40) is abundantly expressed in pancreatic beta cells in rodents, where it facilitates glucose-induced insulin secretion in response to mid- to long-chain fatty acids in vitro. However, GPR40 gene expression in humans has not been fully investigated, and little is known about the physiological and pathophysiological roles of GPR40 in humans. The aim of this study, therefore, was to examine GPR40 expression and its clinical implications in humans.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
0012-186X
|
|
pubmed:author |
pubmed-author:DoiRR,
pubmed-author:EbiharaKK,
pubmed-author:FujikuraJJ,
pubmed-author:FujimotoKK,
pubmed-author:HosodaKK,
pubmed-author:ImamuraMM,
pubmed-author:IwakuraHH,
pubmed-author:KawaguchiYY,
pubmed-author:KawamuraJJ,
pubmed-author:KomotoII,
pubmed-author:MasuzakiHH,
pubmed-author:NakaiMM,
pubmed-author:NoguchiMM,
pubmed-author:ShimadaYY,
pubmed-author:TanakaTT,
pubmed-author:TomitaTT
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
49
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
962-8
|
|
pubmed:dateRevised |
2011-11-17
|
|
pubmed:meshHeading |
pubmed-meshheading:16525841-Adult,
pubmed-meshheading:16525841-Aged,
pubmed-meshheading:16525841-Female,
pubmed-meshheading:16525841-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:16525841-Humans,
pubmed-meshheading:16525841-Insulin,
pubmed-meshheading:16525841-Insulinoma,
pubmed-meshheading:16525841-Islets of Langerhans,
pubmed-meshheading:16525841-Male,
pubmed-meshheading:16525841-Middle Aged,
pubmed-meshheading:16525841-Pancreatic Neoplasms,
pubmed-meshheading:16525841-Receptors, G-Protein-Coupled
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Expression of the gene for a membrane-bound fatty acid receptor in the pancreas and islet cell tumours in humans: evidence for GPR40 expression in pancreatic beta cells and implications for insulin secretion.
|
|
pubmed:affiliation |
Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Sakyo-ku, Kyoto, 606-8507, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
