rdf:type |
|
lifeskim:mentions |
umls-concept:C0006812,
umls-concept:C0013216,
umls-concept:C0016360,
umls-concept:C0030705,
umls-concept:C0205156,
umls-concept:C0205179,
umls-concept:C0213799,
umls-concept:C0231175,
umls-concept:C0282460,
umls-concept:C0442027,
umls-concept:C1527178,
umls-concept:C1527249,
umls-concept:C1705938
|
pubmed:issue |
4
|
pubmed:dateCreated |
2006-5-9
|
pubmed:abstractText |
Rubitecan (RFS-2000, 9NC, Orathecin) is an orally bioavailable camptothecin analogue, with evidence of preclinical activity in colon cancer cell lines. We evaluated oral rubitecan (5 days on, 2 days rest per week) on a continuous schedule, in patients with advanced colorectal cancer (CRC), who progressed after 5-fluorouracil based chemotherapy.
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jul
|
pubmed:issn |
0167-6997
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
24
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
359-63
|
pubmed:dateRevised |
2007-12-3
|
pubmed:meshHeading |
pubmed-meshheading:16525767-Administration, Oral,
pubmed-meshheading:16525767-Adult,
pubmed-meshheading:16525767-Aged,
pubmed-meshheading:16525767-Antineoplastic Agents,
pubmed-meshheading:16525767-Camptothecin,
pubmed-meshheading:16525767-Colorectal Neoplasms,
pubmed-meshheading:16525767-Drug Resistance, Neoplasm,
pubmed-meshheading:16525767-Female,
pubmed-meshheading:16525767-Fluorouracil,
pubmed-meshheading:16525767-Humans,
pubmed-meshheading:16525767-Male,
pubmed-meshheading:16525767-Middle Aged,
pubmed-meshheading:16525767-Survival Analysis,
pubmed-meshheading:16525767-Treatment Failure,
pubmed-meshheading:16525767-Treatment Outcome
|
pubmed:year |
2006
|
pubmed:articleTitle |
Phase II study of rubitecan, an oral camptothecin in patients with advanced colorectal cancer who have failed previous 5-fluorouracil based chemotherapy.
|
pubmed:affiliation |
Division of Hematology/Oncology, Department of Medicine, University of Pittsburgh School of Medicine and Cancer Institute, Pittsburgh, PA 15213, USA.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Clinical Trial, Phase II,
Research Support, N.I.H., Extramural
|