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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
|
pubmed:dateCreated |
1991-9-27
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pubmed:abstractText |
The amplitude-temporal characteristics of miniature end-plate currents (MEPC) were studied in denervated frog cutaneous-pectoral muscles. After the nerve cutting, the initial shortening of MEPC decay time was followed by its prolongation. In 6-8 days after the denervation, the MEPC sensitivity to membrane potential decreased, while the average open time of ACh-activated channels increased 2-fold. The autocorrelation function of ACh-induced current noise revealed two components at some of the synapses. The denervation of the frog cutaneous-pectoral muscle seems to make the postsynaptic membrane to contain two types of ACh receptors (AChR): normal synaptic AChR which gradually disappear, and new synthesized AChRs which open the channels with much longer mean time and a lesser sensitivity to membrane potential changes.
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pubmed:language |
rus
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Feb
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pubmed:issn |
0015-329X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
77
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
57-65
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1652517-Acetylcholine,
pubmed-meshheading:1652517-Animals,
pubmed-meshheading:1652517-Armin,
pubmed-meshheading:1652517-Membrane Potentials,
pubmed-meshheading:1652517-Motor Endplate,
pubmed-meshheading:1652517-Muscle Denervation,
pubmed-meshheading:1652517-Neuromuscular Junction,
pubmed-meshheading:1652517-Ranidae,
pubmed-meshheading:1652517-Receptors, Cholinergic,
pubmed-meshheading:1652517-Receptors, Neurotransmitter,
pubmed-meshheading:1652517-Time Factors
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pubmed:year |
1991
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pubmed:articleTitle |
[The early postdenervation changes in the properties of the postsynaptic membrane of amphibian muscle fiber].
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pubmed:publicationType |
Journal Article,
Comparative Study,
In Vitro,
English Abstract
|