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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1991-10-1
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pubmed:abstractText |
We present evidence for the possible involvement of both the RB and p53 proteins in the regulation of cellular senescence. Human fibroblasts immortalized with an inducible SV40 T-antigen become senescent following the de-induction of T-antigen. Plasmids expressing an alternative source of intact T-antigen restore proliferation but T-antigen deletion mutants lacking either the RB or p53 binding domains are unable to do so. Similarly, combinations of adenovirus E1A + E1B or human papillomavirus E6 + E7 genes are able to replace T-antigen functions and permit cell proliferation, whereas the individual genes do not. These results are discussed in terms of a two-stage model for the escape from in vitro cellular senescence.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0014-4827
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
196
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
33-9
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:1652450-Adenoviruses, Human,
pubmed-meshheading:1652450-Antigens, Viral, Tumor,
pubmed-meshheading:1652450-Cell Division,
pubmed-meshheading:1652450-Cell Survival,
pubmed-meshheading:1652450-Cells, Cultured,
pubmed-meshheading:1652450-Genes, Viral,
pubmed-meshheading:1652450-Humans,
pubmed-meshheading:1652450-Lung,
pubmed-meshheading:1652450-Mutation,
pubmed-meshheading:1652450-Papillomaviridae,
pubmed-meshheading:1652450-Plasmids,
pubmed-meshheading:1652450-Retinoblastoma Protein,
pubmed-meshheading:1652450-Simian virus 40,
pubmed-meshheading:1652450-Tumor Suppressor Protein p53
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pubmed:year |
1991
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pubmed:articleTitle |
A role for both RB and p53 in the regulation of human cellular senescence.
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pubmed:affiliation |
Department of Cell Biology and Neuroscience, University of Texas, Southwestern Medical Center, Dallas 75235.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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