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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-10-2
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pubmed:abstractText |
Bovine brain gangliosides have been shown to prevent decay in Na+,K(+)-ATPase activity in sciatic and optic nerves of alloxan- and streptozotocin-diabetic rats. In the search for a drug with greater bioavailability and increased incorporation into neural tissue, ganglioside inner ester derivatives (AGF1) were recently developed. We evaluated the effect of AGF1 treatment on Na+,K(+)-ATPase activity in homogenates of vagus nerve from alloxan-diabetic rats (100 mg/kg s.c.). Animals were treated with AGF1: 10 mg/kg 6 days/week i.p., or 30 mg/kg biweekly i.p. Treatment began 10 d post-alloxan and continued for 8 consecutive weeks. Normal age- and sex-matched rats were used as controls. Alloxan intoxication produced a 39% decrease in Na+,K(+)-ATPase activity of the vagus nerve, which was completely restored (96-97% recovery) by both AGF1 regimes. Results suggest that ganglioside inner ester derivatives may be used in the clinical setting for the management of diabetic autonomic neuropathy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0168-8227
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
107-11
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1652421-Animals,
pubmed-meshheading:1652421-Blood Glucose,
pubmed-meshheading:1652421-Body Weight,
pubmed-meshheading:1652421-Ca(2+) Mg(2+)-ATPase,
pubmed-meshheading:1652421-Diabetes Mellitus, Experimental,
pubmed-meshheading:1652421-Diabetic Neuropathies,
pubmed-meshheading:1652421-G(M1) Ganglioside,
pubmed-meshheading:1652421-Gangliosides,
pubmed-meshheading:1652421-Hemoglobin A, Glycosylated,
pubmed-meshheading:1652421-Male,
pubmed-meshheading:1652421-Molecular Structure,
pubmed-meshheading:1652421-Rats,
pubmed-meshheading:1652421-Rats, Inbred Strains,
pubmed-meshheading:1652421-Reference Values,
pubmed-meshheading:1652421-Sodium-Potassium-Exchanging ATPase,
pubmed-meshheading:1652421-Vagus Nerve
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pubmed:year |
1991
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pubmed:articleTitle |
Inner ester derivatives of gangliosides protect autonomic nerves of alloxan-diabetic rats against Na+, K(+)-ATPase activity defects.
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pubmed:affiliation |
Mario Negri Institute for Pharmacological Research, Milan, Italy.
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pubmed:publicationType |
Journal Article
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