Linked Life Data

16522456

Source:http://linkedlifedata.com/resource/pubmed/id/16522456

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-3-8
pubmed:abstractText
The contribution of CD8+ T cells to the development of airway hyperresponsiveness and airway inflammation has received increased attention recently. CD8+ T cells, which are capable of secreting TH2 cytokines, including IL-4, IL-5, and IL-13, have been described in asthmatic subjects and in animals sensitized and challenged with allergen. A subset of these IL-13-producing CD8+ T cells, effector memory CD8+ T cells in the mouse, express a high-affinity receptor for leukotriene B4 (BLT1), and expression of this receptor is essential for their accumulation in the lung and development of airway hyperresponsiveness and airway inflammation. A similar subset of CD8+/BLT1+/IL-13+ T cells has also been identified in the bronchoalveolar lavage fluid of asthmatic subjects, suggesting a pathogenic role for this unique subset of CD8+ T cells in asthma.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0091-6749
pubmed:author
pubmed:issnType
Print
pubmed:volume
117
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
577-82
pubmed:dateRevised
2008-4-10
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
CD8+ T lymphocytes and leukotriene B4: novel interactions in the persistence and progression of asthma.
pubmed:affiliation
Division of Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, Denver, CO 80206, USA. gelfande@njc.org
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Review, Research Support, N.I.H., Extramural