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rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
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|
pubmed:dateCreated |
2006-3-31
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|
pubmed:abstractText |
Purine analogs and alkylators are important agents for treating chronic lymphocytic leukemia (CLL). Early studies combining fludarabine and chlorambucil were abandoned owing to increased toxicity from overlapping myelosuppression and immunosuppression. Of the purine analogs active in CLL, pentostatin appears to be the least myelosuppressive. We previously reported that pentostatin and cyclophosphamide (PC) is active and well-tolerated in patients with relapsed or refractory CLL. Subsequently, we added rituximab, and now report on this three-drug combination.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
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|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
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|
pubmed:month |
Apr
|
|
pubmed:issn |
1527-7755
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|
pubmed:author |
pubmed-author:BrentjensRenierR,
pubmed-author:GencarelliAlisonA,
pubmed-author:HeaneyMarkM,
pubmed-author:HorganDeniseD,
pubmed-author:JurcicJoseph GJG,
pubmed-author:KalaycioMattM,
pubmed-author:LamannaNicoleN,
pubmed-author:MaslakPeterP,
pubmed-author:PanageasKatherine SKS,
pubmed-author:ScheinbergDavid ADA,
pubmed-author:WeissMark AMA,
pubmed-author:ZelenetzAndrew DAD
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|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
24
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
1575-81
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|
pubmed:dateRevised |
2010-11-18
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|
pubmed:meshHeading |
pubmed-meshheading:16520464-Adult,
pubmed-meshheading:16520464-Aged,
pubmed-meshheading:16520464-Aged, 80 and over,
pubmed-meshheading:16520464-Antibodies, Monoclonal,
pubmed-meshheading:16520464-Antibodies, Monoclonal, Murine-Derived,
pubmed-meshheading:16520464-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:16520464-Cyclophosphamide,
pubmed-meshheading:16520464-Female,
pubmed-meshheading:16520464-Humans,
pubmed-meshheading:16520464-Leukemia, Lymphocytic, Chronic, B-Cell,
pubmed-meshheading:16520464-Male,
pubmed-meshheading:16520464-Middle Aged,
pubmed-meshheading:16520464-Pentostatin
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pubmed:year |
2006
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|
pubmed:articleTitle |
Pentostatin, cyclophosphamide, and rituximab is an active, well-tolerated regimen for patients with previously treated chronic lymphocytic leukemia.
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|
pubmed:affiliation |
Leukemia Service, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
