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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
1991-9-25
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pubmed:abstractText |
2'-Deoxyuridines with a five-membered heterocyclic substituent in the 5-position were synthesized by palladium-catalyzed coupling reactions of 5-iodo-2'-deoxyuridine with the activated heteroaromatics. Further modification of the compound with the 5-thien-2-yl substituent gave 5-(5-bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothienyl-2-yl)-2'-deoxyuridine. Both compounds show potent and selective activity against herpes simplex virus type 1 and varicella-zoster virus.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0022-2623
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
34
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2383-9
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1652017-Antiviral Agents,
pubmed-meshheading:1652017-Bromodeoxyuridine,
pubmed-meshheading:1652017-Chemical Phenomena,
pubmed-meshheading:1652017-Chemistry,
pubmed-meshheading:1652017-Deoxyuridine,
pubmed-meshheading:1652017-Herpesvirus 3, Human,
pubmed-meshheading:1652017-Molecular Structure,
pubmed-meshheading:1652017-Simplexvirus,
pubmed-meshheading:1652017-Structure-Activity Relationship,
pubmed-meshheading:1652017-Thiophenes,
pubmed-meshheading:1652017-Virus Replication
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pubmed:year |
1991
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pubmed:articleTitle |
5-(5-Bromothien-2-yl)-2'-deoxyuridine and 5-(5-chlorothien-2-yl)-2'-deoxyuridine are equipotent to (E)-5-(2-bromovinyl)-2'-deoxyuridine in the inhibition of herpes simplex virus type I replication.
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pubmed:affiliation |
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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