| pubmed-article:16519896 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16519896 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16519896 | lifeskim:mentions | umls-concept:C1801960 | lld:lifeskim |
| pubmed-article:16519896 | lifeskim:mentions | umls-concept:C0290137 | lld:lifeskim |
| pubmed-article:16519896 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:16519896 | pubmed:dateCreated | 2006-3-27 | lld:pubmed |
| pubmed-article:16519896 | pubmed:abstractText | Given the well-defined role of LIM-motif containing proteins in cytoskeletal organization, cell fate, and differentiation, we hypothesized that the regulation of LIM proteins played an integral role in vascular remodeling. We screened a compendium of cDNA microarray data from rat vascular smooth muscle cells (VSMC) for novel LIM-containing targets and identified muscle LIM protein (MLP), a gene previously thought to be only in striated muscle. Sequence analysis, RTQPCR and Western blotting reconfirmed expression of MLP in VSMC. MLP was elevated>10-fold 7 days following balloon injury in the rat carotid artery. Wire injury led to a significantly increased intima/media ratio in MLP -/- mice compared to wild-type controls (P<0.007, N=5). Fas-ligand and ceramide-induced apoptosis were significantly decreased in MLP deficient VSMC (n=6, P<0.001). Adenoviral-induced restoration of MLP significantly restored apoptotic response (N=6, P<0.001). These findings are the first to identify MLP in vascular smooth muscle and demonstrate that it plays a critical role in vascular remodeling. This is consistent with earlier findings demonstrating a role for MLP in striated muscle remodeling in response to load and stretch. | lld:pubmed |
| pubmed-article:16519896 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16519896 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16519896 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16519896 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16519896 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16519896 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:16519896 | pubmed:issn | 0022-2828 | lld:pubmed |
| pubmed-article:16519896 | pubmed:author | pubmed-author:WangXiaohongX | lld:pubmed |
| pubmed-article:16519896 | pubmed:author | pubmed-author:HallJennifer... | lld:pubmed |
| pubmed-article:16519896 | pubmed:author | pubmed-author:LiQingluQ | lld:pubmed |
| pubmed-article:16519896 | pubmed:author | pubmed-author:AdhikariNeeta... | lld:pubmed |
| pubmed-article:16519896 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16519896 | pubmed:volume | 40 | lld:pubmed |
| pubmed-article:16519896 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16519896 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16519896 | pubmed:pagination | 503-9 | lld:pubmed |
| pubmed-article:16519896 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16519896 | pubmed:meshHeading | pubmed-meshheading:16519896... | lld:pubmed |
| pubmed-article:16519896 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16519896 | pubmed:articleTitle | A role for muscle LIM protein (MLP) in vascular remodeling. | lld:pubmed |
| pubmed-article:16519896 | pubmed:affiliation | Lillehei Heart Institute, Division of Cardiology, Department of Medicine, University of Minnesota, 420 Delaware Street SE, Mayo Mail Code 508, Minneapolis, MN 55455, USA. | lld:pubmed |
| pubmed-article:16519896 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16519896 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:16519896 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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