Linked Life Data

16518700

Source:http://linkedlifedata.com/resource/pubmed/id/16518700

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-3-6
pubmed:abstractText
There is increasing support for the notion that genetic variation for lifespan, both within and between species, is correlated with variation in the efficiency of the free radical scavenging system and the ability to withstand oxidative stress. In Drosophila, resistance to dietary paraquat, a free radical generator, is often used as a measure of resistance to oxidative stress and is reported to give firm positive correlations with longevity. Recently it has been suggested that an increase in antioxidative defences in Drosophila only has a beneficial effect in relatively short-lived stocks. This implies that mechanisms of lifespan determination can be different in lines with different genetic constitution. Here we test if variation in resistance to dietary paraquat co-segregates with variation in lifespan in two sets of Drosophila melanogaster lines that were selected for decreased and increased virgin lifespan respectively. Flies of the short-lived lines show decreased resistance to paraquat compared to the control lines, indicating low resistance against oxidative stress. On the other hand, both males and females of the long-lived lines show, despite increased feeding rates on paraquat-supplemented food, no decreased survival compared to control lines. This shows that flies of the long-lived lines have increased paraquat resistance, but that this is masked by increased feeding rate, resulting in increased exposure to paraquat. This suggests that resistance to paraquat is a correlated response to selection on virgin lifespan over the entire genetic range.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1389-5729
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-95
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Resistance to oxidative stress induced by paraquat correlates well with both decreased and increased lifespan in Drosophila melanogaster.
pubmed:affiliation
Evolutionary Genetics, University of Groningen, NL-9751, NN, Haren, The Netherlands. corneel.vermeulen@biology.au.dk
pubmed:publicationType
Journal Article