| pubmed-article:16517405 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C0178539 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C0242184 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C0311400 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C0043655 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C0392673 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C1707719 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16517405 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16517405 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16517405 | pubmed:dateCreated | 2006-3-6 | lld:pubmed |
| pubmed-article:16517405 | pubmed:abstractText | Activation of glycolytic genes by HIF-1 is considered critical for metabolic adaptation to hypoxia through increased conversion of glucose to pyruvate and subsequently to lactate. We found that HIF-1 also actively suppresses metabolism through the tricarboxylic acid cycle (TCA) by directly trans-activating the gene encoding pyruvate dehydrogenase kinase 1 (PDK1). PDK1 inactivates the TCA cycle enzyme, pyruvate dehydrogenase (PDH), which converts pyruvate to acetyl-CoA. Forced PDK1 expression in hypoxic HIF-1alpha null cells increases ATP levels, attenuates hypoxic ROS generation, and rescues these cells from hypoxia-induced apoptosis. These studies reveal a hypoxia-induced metabolic switch that shunts glucose metabolites from the mitochondria to glycolysis to maintain ATP production and to prevent toxic ROS production. | lld:pubmed |
| pubmed-article:16517405 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16517405 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16517405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16517405 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16517405 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:16517405 | pubmed:issn | 1550-4131 | lld:pubmed |
| pubmed-article:16517405 | pubmed:author | pubmed-author:SemenzaGregg... | lld:pubmed |
| pubmed-article:16517405 | pubmed:author | pubmed-author:DangChi VCV | lld:pubmed |
| pubmed-article:16517405 | pubmed:author | pubmed-author:KimJung-whanJ... | lld:pubmed |
| pubmed-article:16517405 | pubmed:author | pubmed-author:TchernyshyovI... | lld:pubmed |
| pubmed-article:16517405 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16517405 | pubmed:volume | 3 | lld:pubmed |
| pubmed-article:16517405 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16517405 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16517405 | pubmed:pagination | 177-85 | lld:pubmed |
| pubmed-article:16517405 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:meshHeading | pubmed-meshheading:16517405... | lld:pubmed |
| pubmed-article:16517405 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16517405 | pubmed:articleTitle | HIF-1-mediated expression of pyruvate dehydrogenase kinase: a metabolic switch required for cellular adaptation to hypoxia. | lld:pubmed |
| pubmed-article:16517405 | pubmed:affiliation | Graduate Program of Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA. | lld:pubmed |
| pubmed-article:16517405 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16517405 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
| entrez-gene:5163 | entrezgene:pubmed | pubmed-article:16517405 | lld:entrezgene |
| entrez-gene:15251 | entrezgene:pubmed | pubmed-article:16517405 | lld:entrezgene |
| entrez-gene:228026 | entrezgene:pubmed | pubmed-article:16517405 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16517405 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:16517405 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16517405 | lld:pubmed |
