Linked Life Data

16517032

Source:http://linkedlifedata.com/resource/pubmed/id/16517032

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
17
pubmed:dateCreated
2006-3-29
pubmed:abstractText
Different immunization strategies have been implemented for the control of serogroup C meningococcal disease (CMD) in Canada and in other developed countries. Results from effectiveness studies of conjugate vaccines in the UK and Spain indicate waning immunity over time. To estimate the life-time protection conferred by different immunization schedules, a simulation model was constructed based on the current epidemiologic situation in Canada. Results showed that the efficacy of any immunization schedule was highly influenced by the rate at which immunity waned and that the benefit of a booster dose increased with increasing rates of waning immunity. Schedules including several doses in early infancy provided little additional benefit over programs starting with 1 dose at the age of 12 months. One-dose programs provided low levels of protection, unless the vaccine was administered at the age of 12 months, and a waning immunity rate of 1% per year or less was assumed. The most effective schedule was 5 doses given at age 2 months, 4 months, 1 year, 12 years, and 18 years, but was only marginally better than 2 doses provided at 12 months and 12 years of age. Existing routine immunization schedules may not be optimal and should be designed to achieve the highest level of protection using the lowest number of doses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0264-410X
pubmed:author
pubmed:issnType
Print
pubmed:day
24
pubmed:volume
24
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3500-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Relative efficacy of different immunization schedules for the prevention of serogroup C meningococcal disease: a model-based evaluation.
pubmed:affiliation
Faculty of Medicine, Laval University, and Quebec National Institute of Public Health, Canada. Philippe.Dewals@msp.ulaval.ca
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't