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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-4-3
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pubmed:abstractText |
Potent inhibitors of the human PDE IV enzyme are described. Substituted 8-arylquinoline analogs bearing nitrogen-linked side chain were identified as potent inhibitors based on the SAR described herein. The pharmacokinetic profile of the best analog and the in vivo efficacy in an ovalbumin-induced bronchoconstriction assay in conscious guinea pigs are reported.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:CharlesonStellaS,
pubmed-author:DeschênesDenisD,
pubmed-author:DubéDanielD,
pubmed-author:DubéLaurenceL,
pubmed-author:GallantMichelM,
pubmed-author:GirardYvesY,
pubmed-author:HuangZhengZ,
pubmed-author:LacombePatrickP,
pubmed-author:LalibertéFranceF,
pubmed-author:LiuSusanaS,
pubmed-author:MacdonaldDwightD,
pubmed-author:ManciniJoseph AJA,
pubmed-author:MassonPaulP,
pubmed-author:MastracchioAntonyA,
pubmed-author:PerrierHélèneH,
pubmed-author:SalemMyriamM,
pubmed-author:StyhlerAngelaA
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
16
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
2608-12
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pubmed:meshHeading |
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pubmed:year |
2006
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pubmed:articleTitle |
Nitrogen-bridged substituted 8-arylquinolines as potent PDE IV inhibitors.
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pubmed:affiliation |
Merck Frosst Center for Therapeutic Research, PO Box 1005, Pointe Claire-Dorval, Que., Canada H9R 4P8. patrick_lacombe@merck.com
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pubmed:publicationType |
Journal Article
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