Linked Life Data

16516350

Source:http://linkedlifedata.com/resource/pubmed/id/16516350

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-5-2
pubmed:abstractText
Molecular orbital energies of energetically minimized series of extended aromatic and aminoalkyl side chain substituted phenothiazine compounds have been considered with respect to charge transfer (CT) binding properties to P-glycoprotein (P-gp) amino acids of the first P-gp loop. A dependency of decreasing energies of lowest unoccupied orbitals (E(lumo)) with reduced CT binding properties to an increasing P-gp mediated multidrug resistance (MDR) has been found for the extended aromatic compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0223-5234
pubmed:author
pubmed:issnType
Print
pubmed:volume
41
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
548-51
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Correlation of calculated molecular orbital energies of some phenothiazine compounds with MDR reversal properties.
pubmed:affiliation
Department of Pharmacy, Institute of Pharmaceutical Chemistry, Martin-Luther University Halle-Wittenberg, Germany. hilgeroth@pharmazie.uni-halle.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't