| pubmed-article:16515886 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0040811 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0005953 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0002726 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0282637 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C1413206 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0023693 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0699748 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C1524075 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0392762 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C1524063 | lld:lifeskim |
| pubmed-article:16515886 | lifeskim:mentions | umls-concept:C0337112 | lld:lifeskim |
| pubmed-article:16515886 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16515886 | pubmed:dateCreated | 2006-6-20 | lld:pubmed |
| pubmed-article:16515886 | pubmed:abstractText | Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B cells and CD138 plasma cells from the BM of AL patients to delineate the relationship between these two clonal populations. The CD19+ clonal B cells in the BM of AL patients related to the clonal plasma cells represent a pre-plasma cell precursor population. The B cell lineage trees from AL patients also show significant differences in clonal diversification and antigenic selection compared to clones from normal, healthy controls. These data provide a robust example of the use of graphical quantification methods in delineating the role of neoplastic precursors in the pathogenesis of hematopoietic malignancies. | lld:pubmed |
| pubmed-article:16515886 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16515886 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16515886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16515886 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16515886 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:16515886 | pubmed:issn | 1521-6616 | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:DispenzieriAn... | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:GertzMorie... | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:AbrahamRoshin... | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:MehrRamitR | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:ShahafGititG | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:BarakMichalM | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:TimmMichael... | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:EdelmanHannaH | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:ManskeMichell... | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:ZuckermanNeta... | lld:pubmed |
| pubmed-article:16515886 | pubmed:author | pubmed-author:MaidenStephan... | lld:pubmed |
| pubmed-article:16515886 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16515886 | pubmed:volume | 120 | lld:pubmed |
| pubmed-article:16515886 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16515886 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16515886 | pubmed:pagination | 106-20 | lld:pubmed |
| pubmed-article:16515886 | pubmed:dateRevised | 2007-3-22 | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:meshHeading | pubmed-meshheading:16515886... | lld:pubmed |
| pubmed-article:16515886 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16515886 | pubmed:articleTitle | Quantitative analysis of clonal bone marrow CD19+ B cells: use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis. | lld:pubmed |
| pubmed-article:16515886 | pubmed:affiliation | Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. | lld:pubmed |
| pubmed-article:16515886 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16515886 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16515886 | lld:pubmed |
