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rdf:type |
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lifeskim:mentions |
umls-concept:C0002726,
umls-concept:C0004561,
umls-concept:C0005953,
umls-concept:C0023693,
umls-concept:C0035820,
umls-concept:C0040811,
umls-concept:C0282637,
umls-concept:C0337112,
umls-concept:C0392762,
umls-concept:C0699748,
umls-concept:C0936012,
umls-concept:C1413206,
umls-concept:C1522642,
umls-concept:C1524063,
umls-concept:C1524075,
umls-concept:C1704387
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pubmed:issue |
1
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pubmed:dateCreated |
2006-6-20
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pubmed:abstractText |
Light chain amyloidosis (AL) is a bone marrow (BM) plasma cell neoplasia with systemic deposition of Ig light chain amyloid fibrils. Here, we report the identification of clonal CD19 B cells in the BM and the use of a novel mathematical algorithm to generate B cell lineage trees of the clonal CD19 B cells and CD138 plasma cells from the BM of AL patients to delineate the relationship between these two clonal populations. The CD19+ clonal B cells in the BM of AL patients related to the clonal plasma cells represent a pre-plasma cell precursor population. The B cell lineage trees from AL patients also show significant differences in clonal diversification and antigenic selection compared to clones from normal, healthy controls. These data provide a robust example of the use of graphical quantification methods in delineating the role of neoplastic precursors in the pathogenesis of hematopoietic malignancies.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1521-6616
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pubmed:author |
pubmed-author:AbrahamRoshini SRS,
pubmed-author:BarakMichalM,
pubmed-author:DispenzieriAngelaA,
pubmed-author:EdelmanHannaH,
pubmed-author:GertzMorie AMA,
pubmed-author:MaidenStephanieS,
pubmed-author:ManskeMichelle KMK,
pubmed-author:MehrRamitR,
pubmed-author:ShahafGititG,
pubmed-author:TimmMichael MMM,
pubmed-author:ZuckermanNeta SNS
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
106-20
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pubmed:dateRevised |
2007-3-22
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pubmed:meshHeading |
pubmed-meshheading:16515886-Algorithms,
pubmed-meshheading:16515886-Amyloidosis,
pubmed-meshheading:16515886-Antigens, CD19,
pubmed-meshheading:16515886-B-Lymphocytes,
pubmed-meshheading:16515886-Base Sequence,
pubmed-meshheading:16515886-Bone Marrow Diseases,
pubmed-meshheading:16515886-Cell Lineage,
pubmed-meshheading:16515886-Clone Cells,
pubmed-meshheading:16515886-Flow Cytometry,
pubmed-meshheading:16515886-Humans,
pubmed-meshheading:16515886-Immunoglobulin Light Chains,
pubmed-meshheading:16515886-Immunophenotyping,
pubmed-meshheading:16515886-Membrane Glycoproteins,
pubmed-meshheading:16515886-Molecular Sequence Data,
pubmed-meshheading:16515886-Proteoglycans,
pubmed-meshheading:16515886-RNA,
pubmed-meshheading:16515886-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16515886-Sequence Alignment,
pubmed-meshheading:16515886-Sequence Analysis, DNA,
pubmed-meshheading:16515886-Syndecan-1,
pubmed-meshheading:16515886-Syndecans
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pubmed:year |
2006
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pubmed:articleTitle |
Quantitative analysis of clonal bone marrow CD19+ B cells: use of B cell lineage trees to delineate their role in the pathogenesis of light chain amyloidosis.
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pubmed:affiliation |
Division of Hematology, Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, MN 55905, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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