| pubmed-article:1651495 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:1651495 | lifeskim:mentions | umls-concept:C0006675 | lld:lifeskim |
| pubmed-article:1651495 | lifeskim:mentions | umls-concept:C0206181 | lld:lifeskim |
| pubmed-article:1651495 | lifeskim:mentions | umls-concept:C0016904 | lld:lifeskim |
| pubmed-article:1651495 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:1651495 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:1651495 | lifeskim:mentions | umls-concept:C0205171 | lld:lifeskim |
| pubmed-article:1651495 | lifeskim:mentions | umls-concept:C0521116 | lld:lifeskim |
| pubmed-article:1651495 | pubmed:issue | 16 | lld:pubmed |
| pubmed-article:1651495 | pubmed:dateCreated | 1991-9-18 | lld:pubmed |
| pubmed-article:1651495 | pubmed:abstractText | Inhibition of Ca influx and Ca current by gamma-aminobutyric acid (GABA) was studied in single synaptic terminals of isolated retinal bipolar neurons. Measurements of intracellular Ca concentration [( Ca]i) using the fluorescent Ca indicator fura-2 showed that GABA potently inhibited Ca influx into the terminal elicited by high extracellular K concentration ([K]o). This inhibition was attributed to GABA type A (GABAA) receptor-activated chloride ion conductance that prevented bipolar neurons from depolarizing sufficiently to activate the Ca current, even in response to increased [K]o. Patch-clamp recordings of the Ca current revealed a second effect of GABA: GTP-dependent inhibition of the Ca current. This inhibition was not mediated by GABAA receptors, but baclofen, which binds to the GABA type B (GABAB) receptor and is known to inhibit the Ca current in other systems, was not able to mimic the action of GABA. This suggests the involvement of a different type of GABAB-like receptor in the inhibition of Ca current by GABA. GABA did not cause an overall suppression of the Ca current; rather, the voltage-dependence of Ca-channel activation was shifted to more depolarized potentials. Thus, maximal inhibition of the Ca current by GABA occurred in the physiological range of potential. | lld:pubmed |
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| pubmed-article:1651495 | pubmed:language | eng | lld:pubmed |
| pubmed-article:1651495 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:1651495 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1651495 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1651495 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1651495 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:1651495 | pubmed:author | pubmed-author:MatthewsGG | lld:pubmed |
| pubmed-article:1651495 | pubmed:author | pubmed-author:HeidelbergerR... | lld:pubmed |
| pubmed-article:1651495 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1651495 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:1651495 | pubmed:volume | 88 | lld:pubmed |
| pubmed-article:1651495 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1651495 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1651495 | pubmed:pagination | 7135-9 | lld:pubmed |
| pubmed-article:1651495 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:1651495 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1651495 | pubmed:articleTitle | Inhibition of calcium influx and calcium current by gamma-aminobutyric acid in single synaptic terminals. | lld:pubmed |
| pubmed-article:1651495 | pubmed:affiliation | Department of Neurobiology and Behavior, State University of New York, Stony Brook 11794-5230. | lld:pubmed |
| pubmed-article:1651495 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1651495 | pubmed:publicationType | In Vitro | lld:pubmed |
| pubmed-article:1651495 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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