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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
1991-9-18
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pubmed:abstractText |
Inhibition of Ca influx and Ca current by gamma-aminobutyric acid (GABA) was studied in single synaptic terminals of isolated retinal bipolar neurons. Measurements of intracellular Ca concentration [( Ca]i) using the fluorescent Ca indicator fura-2 showed that GABA potently inhibited Ca influx into the terminal elicited by high extracellular K concentration ([K]o). This inhibition was attributed to GABA type A (GABAA) receptor-activated chloride ion conductance that prevented bipolar neurons from depolarizing sufficiently to activate the Ca current, even in response to increased [K]o. Patch-clamp recordings of the Ca current revealed a second effect of GABA: GTP-dependent inhibition of the Ca current. This inhibition was not mediated by GABAA receptors, but baclofen, which binds to the GABA type B (GABAB) receptor and is known to inhibit the Ca current in other systems, was not able to mimic the action of GABA. This suggests the involvement of a different type of GABAB-like receptor in the inhibition of Ca current by GABA. GABA did not cause an overall suppression of the Ca current; rather, the voltage-dependence of Ca-channel activation was shifted to more depolarized potentials. Thus, maximal inhibition of the Ca current by GABA occurred in the physiological range of potential.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-1970471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-212456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-2164405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-2427978,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-2469160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-2557620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-2567963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-3300849,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-3472220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-3838314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-438766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-6097844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-6118434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-6270629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-6420548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-6880034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1651495-7410596
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
88
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
7135-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:1651495-Animals,
pubmed-meshheading:1651495-Baclofen,
pubmed-meshheading:1651495-Calcium,
pubmed-meshheading:1651495-Calcium Channels,
pubmed-meshheading:1651495-Electric Conductivity,
pubmed-meshheading:1651495-Goldfish,
pubmed-meshheading:1651495-Membrane Potentials,
pubmed-meshheading:1651495-Muscimol,
pubmed-meshheading:1651495-Neurons,
pubmed-meshheading:1651495-Picrotoxin,
pubmed-meshheading:1651495-Retina,
pubmed-meshheading:1651495-Synapses,
pubmed-meshheading:1651495-gamma-Aminobutyric Acid
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pubmed:year |
1991
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pubmed:articleTitle |
Inhibition of calcium influx and calcium current by gamma-aminobutyric acid in single synaptic terminals.
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pubmed:affiliation |
Department of Neurobiology and Behavior, State University of New York, Stony Brook 11794-5230.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, P.H.S.
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