Linked Life Data

16513974

Source:http://linkedlifedata.com/resource/pubmed/id/16513974

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5765
pubmed:dateCreated
2006-3-3
pubmed:abstractText
Glutamate, the major excitatory neurotransmitter in the brain, acts primarily on two types of ionotropic receptors: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors and N-methyl-d-aspartate (NMDA) receptors. Work over the past decade indicates that regulated changes in the number of synaptic AMPA receptors may serve as a mechanism for information storage. Recent studies demonstrate that a family of small transmembrane AMPA receptor regulatory proteins (TARPs) controls both AMPA receptor trafficking and channel gating. TARPs provide the first example of auxiliary subunits of ionotropic receptors. Here we review the pivotal role that TARPs play in the life cycle of AMPA receptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1095-9203
pubmed:author
pubmed:issnType
Electronic
pubmed:day
3
pubmed:volume
311
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1253-6
pubmed:dateRevised
2007-3-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Auxiliary subunits assist AMPA-type glutamate receptors.
pubmed:affiliation
Department of Cellular and Molecular Pharmacology, University of California at San Francisco, San Francisco, CA 94143, USA. nicoll@cmp.ucsf.edu
pubmed:publicationType
Journal Article, Review, Research Support, N.I.H., Extramural