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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5771
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pubmed:dateCreated |
2006-4-14
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pubmed:abstractText |
The thymus organ supports the development of T cells and is located in the thorax. Here, we report the existence of a second thymus in the mouse neck, which develops after birth and grows to the size of a small lymph node. The cervical thymus had a typical medulla-cortex structure, was found to support T cell development, and could correct T cell deficiency in athymic nude mice upon transplantation. The identification of a regular second thymus in the mouse may provide evolutionary links to thymus organogenesis in other vertebrates and suggests a need to reconsider the effect of thoracic thymectomy on de novo T cell production.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
14
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pubmed:volume |
312
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
284-7
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pubmed:dateRevised |
2007-3-19
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pubmed:meshHeading |
pubmed-meshheading:16513945-Animals,
pubmed-meshheading:16513945-Animals, Newborn,
pubmed-meshheading:16513945-Choristoma,
pubmed-meshheading:16513945-Forkhead Transcription Factors,
pubmed-meshheading:16513945-Hematopoietic Stem Cells,
pubmed-meshheading:16513945-Hepatitis B Antibodies,
pubmed-meshheading:16513945-Hepatitis B Surface Antigens,
pubmed-meshheading:16513945-Histocompatibility Antigens Class II,
pubmed-meshheading:16513945-Immunocompetence,
pubmed-meshheading:16513945-Lymphopoiesis,
pubmed-meshheading:16513945-Mice,
pubmed-meshheading:16513945-Mice, Inbred BALB C,
pubmed-meshheading:16513945-Mice, Inbred C57BL,
pubmed-meshheading:16513945-Mice, Nude,
pubmed-meshheading:16513945-Neck,
pubmed-meshheading:16513945-Receptors, Antigen, T-Cell,
pubmed-meshheading:16513945-Self Tolerance,
pubmed-meshheading:16513945-T-Lymphocytes,
pubmed-meshheading:16513945-Thymectomy,
pubmed-meshheading:16513945-Thymus Gland
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pubmed:year |
2006
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pubmed:articleTitle |
Evidence for a functional second thymus in mice.
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pubmed:affiliation |
Department of Immunology, University of Ulm, D-89081 Ulm, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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