Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-3-3
pubmed:abstractText
During implantation and pregnancy, the invading trophoblast population is within close contact to maternal immune cells, particularly macrophages. During this period, a low level of trophoblast cell death occurs as part of the normal process of tissue renewal. Macrophage engulfment of apoptotic trophoblast cells prevents the release of potentially pro-immunogenic intracellular contents and prevents a maternal immune response. Furthermore, the uptake of apoptotic cells suppresses macrophages from secreting pro-inflammatory cytokines and promotes the release of anti-inflammatory cytokines, thus creating a microenvironment that will promote trophoblast survival and a successful pregnancy. The present chapter will describe some of the approaches used to study the interaction between macrophages and trophoblast cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:issn
1543-1894
pubmed:author
pubmed:issnType
Print
pubmed:volume
122
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
149-63
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Macrophage-trophoblast interactions.
pubmed:affiliation
Reproductive Immunology Unit, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA.
pubmed:publicationType
Journal Article