Source:http://linkedlifedata.com/resource/pubmed/id/16511980
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:dateCreated |
2006-3-3
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pubmed:abstractText |
During implantation and pregnancy, the invading trophoblast population is within close contact to maternal immune cells, particularly macrophages. During this period, a low level of trophoblast cell death occurs as part of the normal process of tissue renewal. Macrophage engulfment of apoptotic trophoblast cells prevents the release of potentially pro-immunogenic intracellular contents and prevents a maternal immune response. Furthermore, the uptake of apoptotic cells suppresses macrophages from secreting pro-inflammatory cytokines and promotes the release of anti-inflammatory cytokines, thus creating a microenvironment that will promote trophoblast survival and a successful pregnancy. The present chapter will describe some of the approaches used to study the interaction between macrophages and trophoblast cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1543-1894
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
122
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
149-63
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pubmed:meshHeading |
pubmed-meshheading:16511980-Apoptosis,
pubmed-meshheading:16511980-Cell Communication,
pubmed-meshheading:16511980-Cell Culture Techniques,
pubmed-meshheading:16511980-Female,
pubmed-meshheading:16511980-Humans,
pubmed-meshheading:16511980-Macrophages,
pubmed-meshheading:16511980-Phagocytosis,
pubmed-meshheading:16511980-Pregnancy,
pubmed-meshheading:16511980-Trophoblasts
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pubmed:year |
2006
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pubmed:articleTitle |
Macrophage-trophoblast interactions.
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pubmed:affiliation |
Reproductive Immunology Unit, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT, USA.
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pubmed:publicationType |
Journal Article
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