| pubmed-article:1651172 | rdf:type | pubmed:Citation | lld:pubmed |
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| pubmed-article:1651172 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:1651172 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:1651172 | pubmed:dateCreated | 1991-9-18 | lld:pubmed |
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| pubmed-article:1651172 | pubmed:abstractText | We have investigated the feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. We isolated budding yeast mutants sensitive to the anti-microtubule drug benomyl. Mitotic arrest-deficient (mad) mutants are the subclass of benomyl-sensitive mutants in which the completion of mitosis is not delayed in the presence of benomyl and that die as a consequence of their premature exit from mitosis. A number of properties of the mad mutants indicate that they are defective in the feedback control over the exit from mitosis: their killing by benomyl requires passage through mitosis; their benomyl sensitivity can be suppressed by an independent method for delaying the exit from mitosis; they have normal microtubules; and they have increased frequencies of chromosome loss. We cloned MAD2, which encodes a putative calcium-binding protein whose disruption is lethal. We discuss the role of feedback controls in coordinating events in the cell cycle. | lld:pubmed |
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| pubmed-article:1651172 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:1651172 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:1651172 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:1651172 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:1651172 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:1651172 | pubmed:author | pubmed-author:MurrayA WAW | lld:pubmed |
| pubmed-article:1651172 | pubmed:author | pubmed-author:FAYE LEL | lld:pubmed |
| pubmed-article:1651172 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:1651172 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:1651172 | pubmed:volume | 66 | lld:pubmed |
| pubmed-article:1651172 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:1651172 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:1651172 | pubmed:pagination | 519-31 | lld:pubmed |
| pubmed-article:1651172 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:1651172 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:1651172 | pubmed:articleTitle | Feedback control of mitosis in budding yeast. | lld:pubmed |
| pubmed-article:1651172 | pubmed:affiliation | Program in Cell Biology, University of California, San Francisco 94143-0444. | lld:pubmed |
| pubmed-article:1651172 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:1651172 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:1651172 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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