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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-9-18
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pubmed:databankReference |
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M60962,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64383,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64384,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M64707,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/M73821,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S44812,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S44816,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S44821,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S56137,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/S56139,
http://linkedlifedata.com/resource/pubmed/xref/GENBANK/U14132
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pubmed:abstractText |
We have investigated the feedback control that prevents cells with incompletely assembled spindles from leaving mitosis. We isolated budding yeast mutants sensitive to the anti-microtubule drug benomyl. Mitotic arrest-deficient (mad) mutants are the subclass of benomyl-sensitive mutants in which the completion of mitosis is not delayed in the presence of benomyl and that die as a consequence of their premature exit from mitosis. A number of properties of the mad mutants indicate that they are defective in the feedback control over the exit from mitosis: their killing by benomyl requires passage through mitosis; their benomyl sensitivity can be suppressed by an independent method for delaying the exit from mitosis; they have normal microtubules; and they have increased frequencies of chromosome loss. We cloned MAD2, which encodes a putative calcium-binding protein whose disruption is lethal. We discuss the role of feedback controls in coordinating events in the cell cycle.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0092-8674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
9
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pubmed:volume |
66
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
519-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1651172-Amino Acid Sequence,
pubmed-meshheading:1651172-Base Sequence,
pubmed-meshheading:1651172-Benomyl,
pubmed-meshheading:1651172-Calcium-Binding Proteins,
pubmed-meshheading:1651172-Carrier Proteins,
pubmed-meshheading:1651172-Cell Cycle,
pubmed-meshheading:1651172-Cell Cycle Proteins,
pubmed-meshheading:1651172-Cell Nucleus,
pubmed-meshheading:1651172-Chromosomes, Fungal,
pubmed-meshheading:1651172-Cloning, Molecular,
pubmed-meshheading:1651172-Cytoskeleton,
pubmed-meshheading:1651172-DNA, Fungal,
pubmed-meshheading:1651172-DNA Mutational Analysis,
pubmed-meshheading:1651172-Feedback,
pubmed-meshheading:1651172-Fungal Proteins,
pubmed-meshheading:1651172-Genes, Fungal,
pubmed-meshheading:1651172-Microtubules,
pubmed-meshheading:1651172-Mitosis,
pubmed-meshheading:1651172-Mitotic Spindle Apparatus,
pubmed-meshheading:1651172-Molecular Sequence Data,
pubmed-meshheading:1651172-Mutation,
pubmed-meshheading:1651172-Nuclear Proteins,
pubmed-meshheading:1651172-Protamine Kinase,
pubmed-meshheading:1651172-Saccharomyces cerevisiae,
pubmed-meshheading:1651172-Saccharomyces cerevisiae Proteins
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pubmed:year |
1991
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pubmed:articleTitle |
Feedback control of mitosis in budding yeast.
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pubmed:affiliation |
Program in Cell Biology, University of California, San Francisco 94143-0444.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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