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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
Pt 5
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pubmed:dateCreated |
2006-3-2
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pubmed:databankReference |
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pubmed:abstractText |
Protein structures from the causative agent of anthrax (Bacillus anthracis) are being determined as part of a structural genomics programme. Amongst initial candidates for crystallographic analysis are enzymes involved in nucleotide biosynthesis, since these are recognized as potential targets in antibacterial therapy. Purine nucleoside phosphorylase is a key enzyme in the purine-salvage pathway. The crystal structure of purine nucleoside phosphorylase (DeoD) from B. anthracis has been solved by molecular replacement at 2.24 A resolution and refined to an R factor of 18.4%. This is the first report of a DeoD structure from a Gram-positive bacterium.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-10089410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-10320398,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-11743878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-12721629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-15046984,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-15299374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-15299926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-15572765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-2235490,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-7559336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-7584086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-819302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-8332596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16511068-9351810
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1744-3091
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
61
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
459-62
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16511068-Amino Acid Sequence,
pubmed-meshheading:16511068-Bacillus anthracis,
pubmed-meshheading:16511068-Cloning, Organism,
pubmed-meshheading:16511068-Crystallography, X-Ray,
pubmed-meshheading:16511068-Models, Molecular,
pubmed-meshheading:16511068-Molecular Sequence Data,
pubmed-meshheading:16511068-Protein Conformation,
pubmed-meshheading:16511068-Protein Structure, Secondary,
pubmed-meshheading:16511068-Purine-Nucleoside Phosphorylase,
pubmed-meshheading:16511068-Sequence Alignment,
pubmed-meshheading:16511068-Spectrometry, Mass, Electrospray Ionization
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pubmed:year |
2005
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pubmed:articleTitle |
Structure of purine nucleoside phosphorylase (DeoD) from Bacillus anthracis.
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pubmed:affiliation |
Department of Chemistry, University of York, York YO10 5YW, England.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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