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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2006-3-7
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pubmed:abstractText |
It is becoming increasingly apparent that B cells play an important role in the pathogenesis of rheumatoid arthritis (RA). Due to the scarcity of B cells in RA, it has been technically difficult to functionally characterize B cell apoptosis in this disease. As a necessary first step to identify candidate aberrations, we investigated Fas-mediated signaling events in immortalized peripheral blood B lymphoblastoid cell lines (LCLs) from patients with RA and controls.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD95,
http://linkedlifedata.com/resource/pubmed/chemical/CASP3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Caspase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphotransferases (Alcohol Group...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/SKIP protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/sphingosine kinase
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0004-3591
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
54
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
754-64
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16508940-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:16508940-Adult,
pubmed-meshheading:16508940-Aged,
pubmed-meshheading:16508940-Antigens, CD95,
pubmed-meshheading:16508940-Apoptosis,
pubmed-meshheading:16508940-Arthritis, Rheumatoid,
pubmed-meshheading:16508940-B-Lymphocytes,
pubmed-meshheading:16508940-Caspase 3,
pubmed-meshheading:16508940-Caspases,
pubmed-meshheading:16508940-Cell Death,
pubmed-meshheading:16508940-Enzyme Activation,
pubmed-meshheading:16508940-Female,
pubmed-meshheading:16508940-Humans,
pubmed-meshheading:16508940-In Situ Nick-End Labeling,
pubmed-meshheading:16508940-Male,
pubmed-meshheading:16508940-Middle Aged,
pubmed-meshheading:16508940-Phosphotransferases (Alcohol Group Acceptor),
pubmed-meshheading:16508940-Polymerase Chain Reaction,
pubmed-meshheading:16508940-RNA, Messenger,
pubmed-meshheading:16508940-Signal Transduction
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pubmed:year |
2006
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pubmed:articleTitle |
Sphingosine kinase 1-mediated inhibition of Fas death signaling in rheumatoid arthritis B lymphoblastoid cells.
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pubmed:affiliation |
University of Michigan Medical Center, Ann Arbor 48109-0680, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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