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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-5-17
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pubmed:abstractText |
Mantle cell lymphoma (MCL) is an IgM-expressing B cell lymphoma that originates from naive B cells and responds poorly to chemotherapy. We show here that several MCLs harbour isotype-switched subclones. Similar to the situation in normal B cells, in vitro stimulation of MCL cell lines with CD40 ligand (CD40L) and interleukin-4 induced expression of activation-induced cytidine deaminase (AID) and germline transcription at the immunoglobulin heavy chain gene locus. Additionally, the occurrence of switch-circle transcripts and mature IgG transcripts after stimulation indicated ongoing class-switch recombination in mantle cell lymphoma cell lines. Furthermore, stimulation of primary MCL cells in vitro induced expression of class-switched IgG mRNA in the tumour cells. Our data indicate that mantle cell lymphomas have retained the ability to undergo class-switch recombination if appropriate stimuli, such as the CD40 ligand, are provided.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0022-3417
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2006 Pathological Society of Great Britain and Ireland.
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pubmed:issnType |
Print
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pubmed:volume |
209
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
250-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16508921-Antigens, CD40,
pubmed-meshheading:16508921-Cell Line, Tumor,
pubmed-meshheading:16508921-Cytidine Deaminase,
pubmed-meshheading:16508921-Dendritic Cells, Follicular,
pubmed-meshheading:16508921-Genes, Immunoglobulin Heavy Chain,
pubmed-meshheading:16508921-Humans,
pubmed-meshheading:16508921-Immunoglobulin Class Switching,
pubmed-meshheading:16508921-Immunoglobulin G,
pubmed-meshheading:16508921-Immunohistochemistry,
pubmed-meshheading:16508921-Interleukin-4,
pubmed-meshheading:16508921-Lymphoma, Mantle-Cell,
pubmed-meshheading:16508921-Mutation,
pubmed-meshheading:16508921-RNA, Messenger,
pubmed-meshheading:16508921-RNA, Neoplasm,
pubmed-meshheading:16508921-Recombination, Genetic,
pubmed-meshheading:16508921-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16508921-Transcription, Genetic
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pubmed:year |
2006
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pubmed:articleTitle |
Immunoglobulin class-switch recombination occurs in mantle cell lymphomas.
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pubmed:affiliation |
Department of Haematopathology and Lymph Node Registry Kiel, Schleswig-Holstein University Hospitals, Campus Kiel, Niemannsweg 11, 24105 Kiel, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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