| pubmed-article:16508703 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16508703 | lifeskim:mentions | umls-concept:C1622968 | lld:lifeskim |
| pubmed-article:16508703 | lifeskim:mentions | umls-concept:C0020792 | lld:lifeskim |
| pubmed-article:16508703 | lifeskim:mentions | umls-concept:C0003316 | lld:lifeskim |
| pubmed-article:16508703 | lifeskim:mentions | umls-concept:C1136102 | lld:lifeskim |
| pubmed-article:16508703 | lifeskim:mentions | umls-concept:C0205164 | lld:lifeskim |
| pubmed-article:16508703 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:16508703 | pubmed:dateCreated | 2006-7-19 | lld:pubmed |
| pubmed-article:16508703 | pubmed:abstractText | The majority of the neutralizing epitopes of papillomaviruses (PV) are conformation-specific and have not been fully characterised. Studies have, to date, been limited to a few HPV types only. We analysed the epitopes on the major capsid protein (L1) of Human papillomavirus (HPV) type 31 using monoclonal antibodies (MAbs) generated against HPV-31 virus-like particles (VLPs). The type-specific MAbs against HPV-31 were all found to be neutralizing and recognized conformation-dependent epitopes. Two other MAbs directed against a conformational epitope were found to be cross-reactive with other HPV types, and one of them was found to be cross-neutralizing. Cross-reactive antibodies were further investigated using wild-type HPV-16 L1 VLPs and two mutants. The results obtained suggested the existence of a cross-neutralizing conformational epitope at the N-terminal part of the FG loop of the major capsid protein, and the other four cross-reactive MAbs recognized epitopes also located at the N-terminal part of the FG loop. | lld:pubmed |
| pubmed-article:16508703 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16508703 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16508703 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16508703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16508703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16508703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16508703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16508703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16508703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16508703 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16508703 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16508703 | pubmed:month | Aug | lld:pubmed |
| pubmed-article:16508703 | pubmed:issn | 0304-8608 | lld:pubmed |
| pubmed-article:16508703 | pubmed:author | pubmed-author:CoursagetPP | lld:pubmed |
| pubmed-article:16508703 | pubmed:author | pubmed-author:AlvarezEE | lld:pubmed |
| pubmed-article:16508703 | pubmed:author | pubmed-author:ClaverMM | lld:pubmed |
| pubmed-article:16508703 | pubmed:author | pubmed-author:CarpentierGG | lld:pubmed |
| pubmed-article:16508703 | pubmed:author | pubmed-author:TouzéAA | lld:pubmed |
| pubmed-article:16508703 | pubmed:author | pubmed-author:FleuryM J JMJ | lld:pubmed |
| pubmed-article:16508703 | pubmed:author | pubmed-author:VautherotJ-FJ... | lld:pubmed |
| pubmed-article:16508703 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16508703 | pubmed:volume | 151 | lld:pubmed |
| pubmed-article:16508703 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16508703 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16508703 | pubmed:pagination | 1511-23 | lld:pubmed |
| pubmed-article:16508703 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16508703 | pubmed:meshHeading | pubmed-meshheading:16508703... | lld:pubmed |
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| pubmed-article:16508703 | pubmed:meshHeading | pubmed-meshheading:16508703... | lld:pubmed |
| pubmed-article:16508703 | pubmed:meshHeading | pubmed-meshheading:16508703... | lld:pubmed |
| pubmed-article:16508703 | pubmed:meshHeading | pubmed-meshheading:16508703... | lld:pubmed |
| pubmed-article:16508703 | pubmed:meshHeading | pubmed-meshheading:16508703... | lld:pubmed |
| pubmed-article:16508703 | pubmed:meshHeading | pubmed-meshheading:16508703... | lld:pubmed |
| pubmed-article:16508703 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16508703 | pubmed:articleTitle | Identification of type-specific and cross-reactive neutralizing conformational epitopes on the major capsid protein of human papillomavirus type 31. | lld:pubmed |
| pubmed-article:16508703 | pubmed:affiliation | INSERM U618, Université François Rabelais, Tours, France. | lld:pubmed |
| pubmed-article:16508703 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16508703 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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