Linked Life Data

16508301

Source:http://linkedlifedata.com/resource/pubmed/id/16508301

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2006-3-1
pubmed:abstractText
Increasing evidence has shown that the Notch signalling pathway regulates oligodendrogliogenesis. Upon binding to classical Delta/Serrate/Lag-2 ligands, Notch signalling promotes generation of oligodendrocyte precursor cells while inhibiting their further differentiation into myelinating oligodendrocytes. In our recent studies, we have found that two neural cell adhesion molecules, F3/contactin and NB-3 interact with Notch receptors and promote oligodendrocyte development. Remarkably, all these F3 and NB-3/Notch cascade-related events required Deltex1 as the intermediate element. Experiments using several animal models further imply the function of F3/Notch signalling in vivo, which designates Notch signalling as a ligand-dependent, multipotential cascade involved in oligodendrocyte development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-5866
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2006 S. Karger AG, Basel.
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
25-33
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Cross-talk between F3/contactin and Notch at axoglial interface: a role in oligodendrocyte development.
pubmed:affiliation
Institute of Molecular and Cell Biology, Singapore General Hospital, Singapore, Singapore, and Department of Pharmacology and Human Physiology, University of Bari, Italy.
pubmed:publicationType
Journal Article, Review