Source:http://linkedlifedata.com/resource/pubmed/id/16508245
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-4-7
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pubmed:abstractText |
The intracellular serpin, proteinase inhibitor 8 (PI8/Serpinb8), can inhibit furin, a prohormone convertase involved in inflammation, prohormone processing and extracellular matrix remodeling. Unilateral ureteral obstruction (UUO) is a well-characterized model of kidney disease associated with interstitial fibrosis, where recovery involves cellular proliferation and extracellular matrix remodeling. Given the presence of mouse PI8 (mPI8) in kidney, the UUO technique was used to investigate its potential role in kidney disease and regeneration.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0250-8095
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pubmed:author | |
pubmed:copyrightInfo |
Copyright 2006 S. Karger AG, Basel
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pubmed:issnType |
Print
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-42
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pubmed:dateRevised |
2007-2-14
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pubmed:meshHeading |
pubmed-meshheading:16508245-Animals,
pubmed-meshheading:16508245-Fluorescent Antibody Technique,
pubmed-meshheading:16508245-Immunoblotting,
pubmed-meshheading:16508245-Immunohistochemistry,
pubmed-meshheading:16508245-In Situ Hybridization,
pubmed-meshheading:16508245-Kidney,
pubmed-meshheading:16508245-Male,
pubmed-meshheading:16508245-Mice,
pubmed-meshheading:16508245-Mice, Inbred C57BL,
pubmed-meshheading:16508245-Regeneration,
pubmed-meshheading:16508245-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16508245-Serpins,
pubmed-meshheading:16508245-Tissue Distribution,
pubmed-meshheading:16508245-Ureteral Obstruction
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pubmed:year |
2006
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pubmed:articleTitle |
Modulation and redistribution of proteinase inhibitor 8 (Serpinb8) during kidney regeneration.
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pubmed:affiliation |
Department of Biochemistry and Molecular Biology, Monash University, Victoria, Australia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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