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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-9-6
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pubmed:abstractText |
Ischaemic preconditioning is commonly regarded as one of the most powerful protective mechanisms against a subsequent lethal ischaemic injury during coronary artery bypass graft surgery but is not practiced routinely. Experimentally, isoflurane, a commonly used volatile anaesthetic agent, provides myocardial protection through a signal transduction cascade that is remarkably similar to the pathways identified in ischaemic preconditioning. The aim of our study was to investigate whether pre-ischaemic administration of isoflurane exerted protection against prolonged ischaemia with functional recovery and reduced necrosis among patients undergoing coronary artery bypass graft surgery.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0265-0215
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
841-7
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pubmed:meshHeading |
pubmed-meshheading:16507192-Aged,
pubmed-meshheading:16507192-Anesthetics, Inhalation,
pubmed-meshheading:16507192-Biological Markers,
pubmed-meshheading:16507192-Blood Pressure,
pubmed-meshheading:16507192-Cardiac Output,
pubmed-meshheading:16507192-Cardiotonic Agents,
pubmed-meshheading:16507192-Coronary Artery Bypass,
pubmed-meshheading:16507192-Feasibility Studies,
pubmed-meshheading:16507192-Female,
pubmed-meshheading:16507192-Heart Rate,
pubmed-meshheading:16507192-Humans,
pubmed-meshheading:16507192-Ischemic Preconditioning, Myocardial,
pubmed-meshheading:16507192-Isoflurane,
pubmed-meshheading:16507192-Male,
pubmed-meshheading:16507192-Prospective Studies,
pubmed-meshheading:16507192-Stroke Volume,
pubmed-meshheading:16507192-Surgical Procedures, Elective,
pubmed-meshheading:16507192-Time Factors,
pubmed-meshheading:16507192-Treatment Outcome,
pubmed-meshheading:16507192-Troponin I
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pubmed:year |
2006
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pubmed:articleTitle |
Isoflurane preconditioning-induced cardio-protection in patients undergoing coronary artery bypass grafting.
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pubmed:affiliation |
Kaohsiung Veterans General Hospital, Department of Anesthesiology, Taiwan.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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