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rdf:type |
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lifeskim:mentions |
umls-concept:C0008109,
umls-concept:C0039194,
umls-concept:C0079411,
umls-concept:C0079679,
umls-concept:C0086418,
umls-concept:C0206037,
umls-concept:C0599537,
umls-concept:C1160185,
umls-concept:C1518997,
umls-concept:C1524063,
umls-concept:C1533691,
umls-concept:C1623048
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pubmed:dateCreated |
2006-3-27
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pubmed:abstractText |
Genetic redirection of lymphocytes that have been genetically engineered to recognize antigens other than those originally programmed in their germlines is a potentially powerful tool for immunotherapy of cancers and potentially also of persistent viral infections. The basis for this procedure is that both cancers and some viruses have developed strikingly similar mechanisms of evading attacks by host immune mechanisms. To redirect human peripheral blood lymphocytes (PBLs) with a chimeric T cell receptor (chTCR) so that they recognize a new target requires a high degree of transfection efficiency, a process that is regarded as technically demanding.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-10330431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-10383160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-10732766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-11123291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-11191112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-11223069,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-11315507,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-11350882,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-11427731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-11714771,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-11916166,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-12209992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-12384413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-12421958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-12568441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-12670405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-12750268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-1465616,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-15099284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-1533526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-15599402,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-1833767,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-2203551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-2931248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-7522010,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-7690960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-8633023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-8737571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-8891736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9139833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9164948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9221752,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9242523,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9500606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9500607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9541590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9551966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9570292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9625765,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9756399,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9815928,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9935203,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16507098-9973466
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1743-422X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
3
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16507098-Animals,
pubmed-meshheading:16507098-Carcinoembryonic Antigen,
pubmed-meshheading:16507098-Cell Line,
pubmed-meshheading:16507098-Colonic Neoplasms,
pubmed-meshheading:16507098-Genetic Vectors,
pubmed-meshheading:16507098-Humans,
pubmed-meshheading:16507098-Immunotherapy, Adoptive,
pubmed-meshheading:16507098-Lentivirus,
pubmed-meshheading:16507098-Mice,
pubmed-meshheading:16507098-Mice, Inbred BALB C,
pubmed-meshheading:16507098-Receptors, Antigen, T-Cell,
pubmed-meshheading:16507098-Recombinant Fusion Proteins,
pubmed-meshheading:16507098-T-Lymphocytes,
pubmed-meshheading:16507098-Transfection,
pubmed-meshheading:16507098-Vesicular stomatitis Indiana virus
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pubmed:year |
2006
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pubmed:articleTitle |
Use of recombinant lentivirus pseudotyped with vesicular stomatitis virus glycoprotein G for efficient generation of human anti-cancer chimeric T cells by transduction of human peripheral blood lymphocytes in vitro.
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pubmed:affiliation |
Department of Pediatrics, University of Texas Medical Branch, Galveston, Texas, USA. ansimmon@utmb.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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