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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-9-9
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pubmed:abstractText |
Neurotensin (NT), a hypothalamic peptide which is also contained in the chromaffin granules of adrenal medullary cells, did not affect either basal or ACTH-stimulated secretory activity of isolated rat zona glomerulosa (ZG) cells. Conversely, NT was found to exert a strong dose-dependent inhibitory effect on aldosterone response of ZG cells to their two main calcium-dependent secretagogues angiotensin-II and potassium. These findings suggest that NT may interfere with the angiotensin-II- or potassium-induced activation of protein kinase C, possibly by blunting the rise in the cytosolic calcium concentration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0232-7384
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
97
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
34-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1650705-Adrenocorticotropic Hormone,
pubmed-meshheading:1650705-Aldosterone,
pubmed-meshheading:1650705-Angiotensin II,
pubmed-meshheading:1650705-Animals,
pubmed-meshheading:1650705-Dose-Response Relationship, Drug,
pubmed-meshheading:1650705-Male,
pubmed-meshheading:1650705-Mice,
pubmed-meshheading:1650705-Neurotensin,
pubmed-meshheading:1650705-Potassium,
pubmed-meshheading:1650705-Rats,
pubmed-meshheading:1650705-Rats, Inbred Strains,
pubmed-meshheading:1650705-Zona Glomerulosa
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pubmed:year |
1991
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pubmed:articleTitle |
Neurotensin inhibits the stimulatory effect of angiotensin-II and potassium on aldosterone secretion by rat zona glomerulosa cells.
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pubmed:affiliation |
Department of Anatomy, University of Padua, Italy.
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pubmed:publicationType |
Journal Article,
In Vitro
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