Linked Life Data

16506401

Source:http://linkedlifedata.com/resource/pubmed/id/16506401

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-3-1
pubmed:abstractText
Two cannabinoid receptors have been identified to date. The first of these, designated CB1, is localized primarily in the central nervous system but is also present at lower levels in other tissues. The second receptor, CB2, has been found natively in cells of the immune system. Both receptors have an extracellular amine-terminal domain, seven transmembrane domains, an intracellular carboxy-terminal domain, and are coupled through G proteins to adenylate cyclase and mitogen-activated protein kinase. In this chapter, a series of experimental protocols is presented that allows for the systematic identification and localization of cannabinoid receptors in tissues and cells. Immunoperoxidase staining for light microscopy is complemented with correlative application for electron microscopy. This approach is followed by that using immunogold labeling for high-resolution definition of cannabinoid receptor distribution at the ultrastructural level.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1543-1894
pubmed:author
pubmed:issnType
Print
pubmed:volume
123
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
41-69
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Localization of cannabinoid receptors using immunoperoxidase methods.
pubmed:affiliation
Department of Microbiology and Immunology, Virginia Commonwealth University, Richmond, USA.
pubmed:publicationType
Journal Article, Research Support, N.I.H., Extramural