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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-4-10
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pubmed:abstractText |
Lung adenocarcinomas with mutations in exons 19 and 21 of the epidermal growth factor receptor gene (EGFR) demonstrate sensitivity to gefitinib or erlotinib. Investigators have reported an association between EGFR mutations and the amount and duration of cigarette smoking, with the highest incidence of mutations seen in never smokers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1527-7755
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pubmed:author |
pubmed-author:ChuaiShaokunS,
pubmed-author:KrisMark GMG,
pubmed-author:LadanyiMarcM,
pubmed-author:McDonoughTiffaniT,
pubmed-author:MillerVincent AVA,
pubmed-author:PhamDuyKhanhD,
pubmed-author:RielyGregory JGJ,
pubmed-author:RuschValerie WVW,
pubmed-author:SarkariaInderpal SIS,
pubmed-author:SinghBhuvaneshB,
pubmed-author:VenkatramanEnnapadam SES,
pubmed-author:WillettM AMA,
pubmed-author:WilsonRichard KRK
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1700-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16505411-Adenocarcinoma,
pubmed-meshheading:16505411-Exons,
pubmed-meshheading:16505411-Female,
pubmed-meshheading:16505411-Genes, erbB-1,
pubmed-meshheading:16505411-Humans,
pubmed-meshheading:16505411-Incidence,
pubmed-meshheading:16505411-Lung Neoplasms,
pubmed-meshheading:16505411-Male,
pubmed-meshheading:16505411-Molecular Biology,
pubmed-meshheading:16505411-Mutation,
pubmed-meshheading:16505411-Protein Kinase Inhibitors,
pubmed-meshheading:16505411-Quinazolines,
pubmed-meshheading:16505411-ROC Curve,
pubmed-meshheading:16505411-Smoking
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pubmed:year |
2006
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pubmed:articleTitle |
Use of cigarette-smoking history to estimate the likelihood of mutations in epidermal growth factor receptor gene exons 19 and 21 in lung adenocarcinomas.
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pubmed:affiliation |
Department of Surgery, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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