Linked Life Data

16504595

Source:http://linkedlifedata.com/resource/pubmed/id/16504595

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2006-9-11
pubmed:abstractText
Recently, a new member of the secreted frizzled-related protein (sFRP) family, named tlc, has been identified as expressed by the anterior neural border (ANB) cells in the zebrafish Danio rerio. Tlc plays an important role in telencephalic induction and patterning. In absence of Tlc, formation of the telencephalon is severely delayed, but not abolished. This prompted us to clone the other zebrafish sfrp family members and analyse their expression patterns, in search of a family member that may partly functionally overlap with Tlc. Except sizzled, expression profile of sfrp genes in zebrafish has not been reported so far. Here, we describe the cloning of full-length cDNA for sfrp1a, sfrp1b, sfrp2, sfrp3 and sfrp5 gene transcripts and we examine their expression at different embryonic stages. Only sfrp1a is expressed in the anterior neural plate including the ANB cells where and when tlc is expressed. Interestingly, compared to both tlc and sfrp1a, wnt genes are complementary expressed more posteriorly in the neural plate. Later, both sfrp1a and sfrp5 expression profiles are overlapping, in particular at pharyngula stage these genes are expressed in the ventral part of the forebrain, midbrain and hindbrain. sfrp1b, sfrp2 and sfrp3 are mainly expressed in mesodermal and endodermal embryonic tissues. Expression profiles of these different genes in zebrafish gave interesting clues on the possible function and evolution of sFRPs in zebrafish and other organisms.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1567-133X
pubmed:author
pubmed:issnType
Print
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
761-71
pubmed:dateRevised
2007-8-13
pubmed:meshHeading
pubmed-meshheading:16504595-Animals, pubmed-meshheading:16504595-Central Nervous System, pubmed-meshheading:16504595-Cloning, Molecular, pubmed-meshheading:16504595-Conserved Sequence, pubmed-meshheading:16504595-Embryo, Nonmammalian, pubmed-meshheading:16504595-Evolution, Molecular, pubmed-meshheading:16504595-Gastrula, pubmed-meshheading:16504595-Gene Expression Profiling, pubmed-meshheading:16504595-Gene Expression Regulation, Developmental, pubmed-meshheading:16504595-Glycoproteins, pubmed-meshheading:16504595-Intercellular Signaling Peptides and Proteins, pubmed-meshheading:16504595-Phylogeny, pubmed-meshheading:16504595-Proteins, pubmed-meshheading:16504595-Somites, pubmed-meshheading:16504595-Spinal Cord, pubmed-meshheading:16504595-Zebrafish, pubmed-meshheading:16504595-Zebrafish Proteins
pubmed:year
2006
pubmed:articleTitle
Cloning and embryonic expression of five distinct sfrp genes in the zebrafish Danio rerio.
pubmed:affiliation
MRC Centre for Developmental Neurobiology, New Hunt's House, King's College London, London SE1 9RT, United Kingdom.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't